ASYMMETRIC SYNTHESIS OF 1-ALKYL-2-DEOXYIMINOFURANOSES VIA THE IRIDIUM-CATALYZED INTRAMOLECULAR CYCLIZATION OF AN ALLYLIC CARBONATE

被引：7

作者：

Natori, Yoshihiro ^{[1
]}

Kikuchi, Shunsuke ^{[1
]}

Yoshimura, Yuichi ^{[1
]}

Kato, Atsushi ^{[2
]}

Adachi, Isao ^{[2
]}

Takahata, Hiroki ^{[1
]}

机构：

[1] Tohoku Pharmaceut Univ, Fac Pharmaceut Sci, Sendai, Miyagi 9818558, Japan

[2] Toyama Univ, Dept Hosp Pharm, Toyama 9300194, Japan

来源：

HETEROCYCLES | 2012年 / 86卷 / 02期

基金：

日本学术振兴会;

关键词：

1-Alkyl-2-deoxyiminofuranose; Ir-Catalyzed Allylic Cyclization; alpha-Glucosidase Inhibitor; IMINOSUGARS; INHIBITORS;

D O I：

10.3987/COM-12-S(N)99

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An asymmetric synthesis of 1-alkyl-2-deoxyiminofuranoses was achieved in which the Ir-catalyzed intramolecular cyclization was the key step. The diastereoselective cyclization converted an allylic carbonate into pyrrolidine derivatives. The alpha-glucosidase inhibitory activities of the prepared 2-deoxyiminofuranoses were also investigated.

引用

页码：1401 / 1417

页数：17

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