Expression of efflux pump gene lde in ciprofloxacin-resistant foodborne isolates of Listeria monocytogenes

被引：27

作者：

Jiang, Xiaobing ^{[1
,2
,3
]}

Zhou, Lijun ^{[1
]}

Gao, Dongwei ^{[4
]}

Wang, Yuxiao ^{[1
]}

Wang, Dapeng ^{[1
]}

Zhang, Zhigang ^{[3
]}

Chen, Miaorui ^{[3
]}

Su, Yongyu ^{[3
]}

Li, Lin ^{[2
,3
]}

Yan, He ^{[2
,3
]}

Shi, Lei ^{[2
,3
]}

机构：

[1] Cent Lab Navy Gen Hosp, Beijing 100048, Peoples R China

[2] S China Univ Technol, Coll Light Ind & Food Sci, Guangzhou 510640, Guangdong, Peoples R China

[3] Xiamen Yinxiang Grp, State Key Lab Food Safety Technol Meat Prod, Xiamen 361100, Peoples R China

[4] Guangdong Inspect & Quarantine Technol Ctr, Guangzhou 510623, Guangdong, Peoples R China

来源：

MICROBIOLOGY AND IMMUNOLOGY | 2012年 / 56卷 / 12期

关键词：

ciprofloxacin resistance; efflux pump; Listeria monocytogenes; ANTIBIOTIC-RESISTANCE; FOODS;

D O I：

10.1111/j.1348-0421.2012.00506.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The expression of efflux pump gene lde in ciprofloxacin resistant (Cip(R)) and susceptible strains of Listeria monocytogenes collected from retail food samples was investigated. For two Cip(R) strains, the MICs of ciprofloxacin decreased four- to eightfold in the presence of reserpine; however, no significant alterations were observed with naturally sensitive isolates. Overexpression of the lde gene induced by ciprofloxacin was observed in two resistant isolates. The present findings indicate that expression of lde and the MICs of ciprofloxacin are well correlated with the presence and absence of reserpine, suggesting that Lde might be involved in ciprofloxacin resistance of L. monocytogenes.

引用

页码：843 / 846

页数：4

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