SnapShot: The Intestinal Crypt

被引:44
作者
Clevers, Hans [1 ,2 ]
Batlle, Eduard [3 ,4 ]
机构
[1] KNAW, Hubrecht Inst, NL-3584 CT Utrecht, Netherlands
[2] Univ Med Ctr Utrecht, NL-3584 CT Utrecht, Netherlands
[3] Inst Res Biomed IRB Barcelona, Barcelona 08028, Spain
[4] ICREA, Barcelona 08010, Spain
关键词
LGR5; STEM-CELLS; WNT RECEPTORS; HOMEOSTASIS;
D O I
10.1016/j.cell.2013.02.030
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:1198 / +
页数:3
相关论文
共 10 条
[1]   Identification of stem cells in small intestine and colon by marker gene Lgr5 [J].
Barker, Nick ;
van Es, Johan H. ;
Kuipers, Jeroen ;
Kujala, Pekka ;
van den Born, Maaike ;
Cozijnsen, Miranda ;
Haegebarth, Andrea ;
Korving, Jeroen ;
Begthel, Harry ;
Peters, Peter J. ;
Clevers, Hans .
NATURE, 2007, 449 (7165) :1003-U1
[2]  
Buczacki SJ, 2013, NATURE
[3]   Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling [J].
de Lau, Wim ;
Barker, Nick ;
Low, Teck Y. ;
Koo, Bon-Kyoung ;
Li, Vivian S. W. ;
Teunissen, Hans ;
Kujala, Pekka ;
Haegebarth, Andrea ;
Peters, Peter J. ;
van de Wetering, Marc ;
Stange, Daniel E. ;
van Es, Johan E. ;
Guardavaccaro, Daniele ;
Schasfoort, Richard B. M. ;
Mohri, Yasuaki ;
Nishimori, Katsuhiko ;
Mohammed, Shabaz ;
Heck, Albert J. R. ;
Clevers, Hans .
NATURE, 2011, 476 (7360) :293-U57
[4]   De novo crypt formation and juvenile polyposis on BMP inhibition in mouse intestine [J].
Haramis, APG ;
Begthel, H ;
van den Born, M ;
van Es, J ;
Jonkheer, S ;
Offerhaus, GJA ;
Clevers, H .
SCIENCE, 2004, 303 (5664) :1684-1686
[5]   Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors [J].
Koo, Bon-Kyoung ;
Spit, Maureen ;
Jordens, Ingrid ;
Low, Teck Y. ;
Stange, Daniel E. ;
van de Wetering, Marc ;
van Es, Johan H. ;
Mohammed, Shabaz ;
Heck, Albert J. R. ;
Maurice, Madelon M. ;
Clevers, Hans .
NATURE, 2012, 488 (7413) :665-+
[6]   Dll1- and Dll4-Mediated Notch Signaling Are Required for Homeostasis of Intestinal Stem Cells [J].
Pellegrinet, Luca ;
Rodilla, Veronica ;
Liu, Zhenyi ;
Chen, Shuang ;
Koch, Ute ;
Espinosa, Lluis ;
Kaestner, Klaus H. ;
Kopan, Raphael ;
Lewis, Julian ;
Radtke, Freddy .
GASTROENTEROLOGY, 2011, 140 (04) :1230-+
[7]   Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche [J].
Sato, Toshiro ;
Vries, Robert G. ;
Snippert, Hugo J. ;
van de Wetering, Marc ;
Barker, Nick ;
Stange, Daniel E. ;
van Es, Johan H. ;
Abo, Arie ;
Kujala, Pekka ;
Peters, Peter J. ;
Clevers, Hans .
NATURE, 2009, 459 (7244) :262-U147
[8]   Intestinal Crypt Homeostasis Results from Neutral Competition between Symmetrically Dividing Lgr5 Stem Cells [J].
Snippert, Hugo J. ;
van der Flier, Laurens G. ;
Sato, Toshiro ;
van Es, Johan H. ;
van den Born, Maaike ;
Kroon-Veenboer, Carla ;
Barker, Nick ;
Klein, Allon M. ;
van Rheenen, Jacco ;
Simons, Benjamin D. ;
Clevers, Hans .
CELL, 2010, 143 (01) :134-144
[9]   Dll1+ secretory progenitor cells revert to stem cells upon crypt damage [J].
van Es, Johan H. ;
Sato, Toshiro ;
van de Wetering, Marc ;
Lyubimova, Anna ;
Nee, Annie Ng Yee ;
Gregorieff, Alex ;
Sasaki, Nobuo ;
Zeinstra, Laura ;
van den Born, Maaike ;
Korving, Jeroen ;
Martens, Anton C. M. ;
Barker, Nick ;
van Oudenaarden, Alexander ;
Clevers, Hans .
NATURE CELL BIOLOGY, 2012, 14 (10) :1099-+
[10]   Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling [J].
Wong, Vivian W. Y. ;
Stange, Daniel E. ;
Page, Mahalia E. ;
Buczacki, Simon ;
Wabik, Agnieszka ;
Itami, Satoshi ;
van de Wetering, Marc ;
Poulsom, Richard ;
Wright, Nicholas A. ;
Trotter, Matthew W. B. ;
Watt, Fiona M. ;
Winton, Doug J. ;
Clevers, Hans ;
Jensen, Kim B. .
NATURE CELL BIOLOGY, 2012, 14 (04) :401-+