THE MG-QOL15 JAPANESE VERSION: VALIDATION AND ASSOCIATIONS WITH CLINICAL FACTORS

被引：70

作者：

Masuda, Masayuki ^{[2
]}

Utsugisawa, Kimiaki ^{[1
]}

Suzuki, Shigeaki ^{[3
]}

Nagane, Yuriko ^{[1
]}

Kabasawa, Chiaki ^{[4
]}

Suzuki, Yasushi ^{[5
]}

Shimizu, Yuko ^{[4
]}

Utsumi, Hiroya ^{[2
]}

Fujihara, Kazuo ^{[6
]}

Uchiyama, Shinichiro ^{[4
]}

Suzuki, Norihiro ^{[3
]}

机构：

[1] Hanamaki Gen Hosp, Dept Neurol, Hanamaki 0250075, Japan

[2] Tokyo Med Univ, Dept Neurol, Tokyo, Japan

[3] Keio Univ, Sch Med, Dept Neurol, Tokyo, Japan

[4] Sendai Med Ctr, Dept Neurol, Sendai, Miyagi, Japan

[5] Tohoku Univ, Grad Sch Med, Dept Neurol, Sendai, Miyagi 980, Japan

[6] Tokyo Womens Med Univ, Dept Neurol, Tokyo, Japan

来源：

MUSCLE & NERVE | 2012年 / 46卷 / 02期

关键词：

cross-sectional study; health-related quality of life; myasthenia gravis; questionnaire; validity; QUALITY-OF-LIFE; MYASTHENIA-GRAVIS; OUTCOME MEASURE; ADAPTATION; INSTRUMENT;

D O I：

10.1002/mus.23398

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction: Our study aim was to produce a Japanese translation of the 15-item Myasthenia Gravis Quality-of-Life Scale (MG-QOL15), assess its reliability and validity, and examine clinical factors affecting self-perceived QOL in MG. Methods: We evaluated 327 consecutive patients with MG seen at six neurological centers. All patients completed the Japanese version of the MG-QOL15 (MG-QOL15-J), the Beck Depression Inventory-second edition (BDI-II), and a generic health-related QOL questionnaire, the SF-36. Disease severity was determined according to the Myasthenia Gravis Foundation of America (MGFA) quantitative MG score and the MG composite. Results: The MG-QOL15-J exhibited adequate internal reliability, test-retest repeatability, and concurrent validity with SF-36, disease severity, and known-patient groups categorized by MGFA post-intervention status. Multivariate analysis revealed severity, dose of oral corticosteroids, and BDI-II as independent factors negatively affecting QOL. Conclusion: The MG-QOL15J is anticipated to be a valuable clinical measure of QOL in Japanese patients with MG. Muscle Nerve 46: 166-173, 2012

引用

页码：166 / 173

页数：8

共 27 条

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