Macro lncRNAs A new layer of cis-regulatory information in the mammalian genome

被引：63

作者：

Guenzl, Philipp M. ^{[1
]}

Barlow, Denise P. ^{[1
]}

机构：

[1] Austrian Acad Sci, CeMM Res Ctr Mol Med, A-1010 Vienna, Austria

来源：

RNA BIOLOGY | 2012年 / 9卷 / 06期

基金：

奥地利科学基金会;

关键词：

ncRNAs; linc; lnc; macro; genomic imprinting; RNA-seq; INTERGENIC NONCODING RNAS; X-CHROMOSOME INACTIVATION; CORONARY-ARTERY-DISEASE; ANTISENSE RNA; WIDE ASSOCIATION; GENE-EXPRESSION; LYNCH SYNDROME; IDENTIFIES; TRANSCRIPTION; ANRIL;

D O I：

10.4161/rna.19985

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Long non-protein-coding RNAs (lncRNAs) have been shown in the past ten years to comprise a major part of the mammalian transcriptome and are predicted from their highly specific expression patterns, to play a role in regulating protein-coding gene expression in development and disease. Many lncRNAs particularly those lying in imprinted clusters, are predominantly unspliced 'macro' transcripts that can also show a low level of splicing, and both the unspliced and spliced transcript have the potential to be functional. Three known imprinted macro lncRNAs have been shown to silence from three to ten genes in cis in imprinted gene clusters. We review here the potential for functional macro lncRNAs, defined here as 'inefficiently-spliced lncRNAs' to play a wider cis-regulatory role in the mammalian genome. This potential has been underestimated by the inability of current RNA-seq technology to annotate unspliced macro lncRNAs.

引用

页码：731 / 741

页数：11

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