Evaluation and prognostic significance of human tissue kallikrein-related peptidase 10 (KLK10) in colorectal cancer

被引：20

作者：

Petraki, Constantina ^{[1
]}

Youssef, Youssef M. ^{[2
,3
,6
]}

Dubinski, William ^{[2
,3
,6
]}

Lichner, Zsuzsanna ^{[2
,3
,6
]}

Scorilas, Andreas ^{[4
]}

Pasic, Maria D. ^{[2
]}

Komborozos, Vassilios ^{[5
]}

Khalil, Bishoy ^{[3
,6
]}

Streutker, Catherine ^{[2
,3
,6
]}

Diamandis, Eleftherios P. ^{[2
]}

Yousef, George M. ^{[2
,3
,6
]}

机构：

[1] Metropolitan Hosp, Dept Pathol, Athens, Greece

[2] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada

[3] St Michaels Hosp, Dept Lab Med, Toronto, ON M5B 1W8, Canada

[4] Univ Athens, Fac Biol, Dept Biochem & Mol Biol, Athens 15701, Greece

[5] Evangelismos Med Ctr, Dept Gen Surg, Athens, Greece

[6] St Michaels Hosp, Keenan Res Ctr, Li Ka Shing Knowledge Inst, Toronto, ON M5B 1W8, Canada

来源：

TUMOR BIOLOGY | 2012年 / 33卷 / 04期

关键词：

KLK; Kallikreins; KLK10; Colorectal cancer; Prognosis; CLINICAL-SIGNIFICANCE; GENE-EXPRESSION; SERINE-PROTEASE; CELL CARCINOMA; FAMILY; METHYLATION; MARKERS;

D O I：

10.1007/s13277-012-0368-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The prognosis of patients with colorectal cancer (CRC) is assessed through conventional clinicopathological parameters, which are not always accurate. Members of the human kallikrein-related peptidases gene family represent potential cancer biomarkers. The aim of this study was to investigate the expression of human tissue kallikrein-related peptidase 10 (KLK10) by immunohistochemistry in CRC, to correlate this expression with various histopathological and clinical variables, and to evaluate its significance as a predictor of disease outcome. KLK10 expression was evaluated by immunohistochemistry and a combined expression score was calculated for each case based on intensity and percentage of positivity. A statistically significant positive association was observed between KLK10 and tumor stage and liver metastases (p = 0.015 and p = 0.035, respectively). Paradoxically, a negative association was observed between KLK10 and tumor grade (p = 0.009). Kaplan-Meier survival curves and univariate analysis showed that both KLK10 expression and stage had statistically significant correlations with disease-free survival (DFS) (p = 0.030 and p < 0.001, respectively) and overall survival (p = 0.010 and p = 0.001, respectively). Cox multivariate analysis showed that both KLK10 expression and stage were independent predictors of unfavorable DFS (p = 0.057 and p = 0.001, respectively) and overall survival (p = 0.009 and p = 0.001, respectively). In conclusion, KLK10 immunostaining is an independent prognostic marker in patients with CRC.

引用

页码：1209 / 1214

页数：6

共 33 条

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