A high-fat high-energy diet influences hepatic CYP3A expression and activity in low-birth-weight developing female rats

被引：1
作者：
Ni, Shao-Qing [1 ]
Lou, Yin [2 ]
Wang, Xiu-Min [2 ,3 ]
Shen, Zheng [4 ]
Wang, Jue
Zhao, Zheng-Yan [5 ]
Zeng, Su [6 ]
机构：
[1] Zhejiang Univ, Natl Clin Trial Inst, Childrens Hosp, Sch Med, Hangzhou, Zhejiang, Peoples R China
[2] Zhejiang Univ, Dept Pharm, Childrens Hosp, Sch Med, Hangzhou, Zhejiang, Peoples R China
[3] Zhejiang Univ, Dept Endocrinol, Childrens Hosp, Sch Med, Hangzhou, Zhejiang, Peoples R China
[4] Zhejiang Univ, Lab Ctr, Childrens Hosp, Sch Med, Hangzhou, Zhejiang, Peoples R China
[5] Zhejiang Univ, Dept Childrens Hlth & Care, Childrens Hosp, Sch Med, Hangzhou, Zhejiang, Peoples R China
[6] Zhejiang Univ, Dept Pharmaceut Anal & Drug Metab, Coll Pharmaceut Sci, 388 Yu Hang Tang Rd, Hangzhou 310058, Zhejiang, Peoples R China
来源：
WORLD JOURNAL OF PEDIATRICS | 2016年 / 12卷 / 04期
基金：
美国国家科学基金会;
关键词：
CYP3A; development; high-energy diet; low birth weight; DRUG-METABOLIZING-ENZYMES; GENE-EXPRESSION; ADIPOSE-TISSUE; DEVELOPMENTAL EXPRESSION; CYTOCHROMES P450; LIVER; OBESITY; GROWTH; UNDERNUTRITION; NUTRITION;
D O I：
10.1007/s12519-016-0019-9
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Background:The objective of this study was to investigate the effects of a high-fat, high-energy (HFHE) diet on the hepatic expression of CYP3A in low-birth weight developing female rats. Methods:Pregnant rats were divided into nourished and undernourished groups. The offspring of the nourished rats were defined as the normal-birth-weight (NBW) group, and those of undernourished rats were defined as the low-birth-weight (LBW) group. According to their birth weights and diets, the rats were subdivided into the following four groups: NBW-normal diet (NN) group; NBW-HFHE (NH) group; LBW-normal diet (LN) group; and LBW-HFHE (LH) group. Liver samples were isolated on days 3, 7, 14, 21, 28, 56 and 84 after birth. Results:The CYP3A1 mRNA levels in the LH group on days 3, 56 and 84 were significantly higher than those of the NN group (P<0.05). CYP3A1 expression was significantly higher in the LH group than that in the NH group on days 21, 28 and 84 (P<0.05). CYP3A1 mRNA expression was higher in the LH group than that in the LN group on days 3 and 21 (P<0.05). No zonal CYP3A1 expression pattern was observed in the LH developmental group. The LH group had significantly higher mean activity than the LN group on days 7, 14, 28 and 56. Conclusion:Our results indicated that an HFHE diet can result in alterations of CYP3A expression in a developmental LBW rat model.
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收藏
页码：489 / 497
页数：9
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