The Aryl Hydrocarbon Receptor Modulates Acute and Late Mast Cell Responses

被引:64
|
作者
Sibilano, Riccardo [1 ]
Frossi, Barbara [1 ]
Calvaruso, Marco [2 ]
Danelli, Luca [1 ]
Betto, Elena [1 ]
Dall'Agnese, Alessandra [1 ]
Tripodo, Claudio [2 ]
Colombo, Mario P. [3 ]
Pucillo, Carlo E. [1 ]
Gri, Giorgia [1 ]
机构
[1] Univ Udine, Dept Med & Biol Sci, I-33100 Udine, Italy
[2] Univ Palermo, Dept Human Pathol, I-90127 Palermo, Italy
[3] Ist Nazl Tumori, Dipartimento Oncol Sperimentale & Med Mol, Fdn Ist Ricovero & Cura Carattere Sci, I-20133 Milan, Italy
来源
JOURNAL OF IMMUNOLOGY | 2012年 / 189卷 / 01期
关键词
OBSTRUCTIVE PULMONARY-DISEASE; REGULATORY T-CELLS; LUNG FIBROBLASTS; ACTIVATION; EXPRESSION; INTERLEUKIN-6; INFLAMMATION; ASTHMA; DIFFERENTIATION; DEGRANULATION;
D O I
10.4049/jimmunol.1200009
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor whose activity is modulated by xenobiotics as well as physiological ligands. These compounds may modulate inflammatory responses and contribute to the rising prevalence of allergic diseases observed in industrialized countries. Mast cells (MCs), located within tissues at the boundary of the external environment, represent a potential target of AhR ligands. In this study, we report that murine and human MCs constitutively express AhR, and its activation by the high-affinity ligand 6-formylindolo[3,2-b]carbazole (FICZ) determines a boost in degranulation. On the contrary, repeated exposure to FICZ inhibits MC degranulation. Accordingly, histamine release, in an in vivo passive systemic anaphylactic model, is exacerbated by a single dose and is attenuated by repetitive stimulation of AhR. FICZ-exposed MCs produce reactive oxygen species and IL-6 in response to cAMP-dependent signals. Moreover, AhR-activated MCs produce IL-17, a critical player in chronic inflammation and autoimmunity, suggesting a novel pathway for MC activation in the pathogenesis of these diseases. Indeed, histological analysis of patients with chronic obstructive pulmonary disease revealed an enrichment in AhR/IL-6 and AhR/IL-17 double-positive MCs within bronchial lamina propria. Thus, tissue-resident MCs could translate external chemical challenges through AhR by modulating allergic responses and contributing to the generation of inflammation-related diseases. The Journal of Immunology, 2012, 189: 120-127.
引用
收藏
页码:120 / 127
页数:8
相关论文
共 50 条
  • [21] SILENCING OF ARYL HYDROCARBON RECEPTOR REPRESSOR MODULATES Th17-CELL IMMUNITY IN AUTOIMMUNE HEPATITIS
    Gromova, Barbora
    Gao, Li
    Zhang, Wei
    Zhang, Lina
    Nastasio, Silvia
    Bonder, Alan
    Patwardhan, Vilas
    Longhi, Maria Serena
    HEPATOLOGY, 2023, 78 : S2024 - S2024
  • [22] Aryl Hydrocarbon Receptor Nuclear Translocator in Hepatocytes Is Required for Aryl Hydrocarbon Receptor-Mediated Adaptive and Toxic Responses in Liver
    Nukaya, Manabu
    Walisser, Jacqueline A.
    Moran, Susan M.
    Kennedy, Gregory D.
    Bradfield, Christopher A.
    TOXICOLOGICAL SCIENCES, 2010, 118 (02) : 554 - 563
  • [23] The Aryl Hydrocarbon Receptor (AHR) Promotes Late-Stage Human NK Cell Maturation
    Sara, Kinda
    Ruesch, Michael
    Mundy-Bosse, Bethany
    Freud, Aharon
    JOURNAL OF IMMUNOLOGY, 2024, 212 (01):
  • [24] Role of the Aryl-hydrocarbon Receptor (AhR)-ligand Axis in Mast Cells
    Zhou, Y.
    Tung, H.
    Tsai, Y.
    Hsu, S.
    Plunkett, B.
    Vonakis, B. M.
    Huang, S.
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2012, 129 (02) : AB121 - AB121
  • [25] Modulation of Immune Responses by Nutritional Ligands of Aryl Hydrocarbon Receptor
    De Juan, Alba
    Segura, Elodie
    FRONTIERS IN IMMUNOLOGY, 2021, 12
  • [26] Metformin inhibits IgE- and aryl hydrocarbon receptor-mediated mast cell activation in vitro and in vivo
    Wang, Hsueh-Chun
    Huang, Shau-Ku
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2018, 48 (12) : 1989 - 1996
  • [27] Thrombin receptor activation modulates mast cell reactivity
    Strukova, S
    Umarova, B
    Dugina, T
    Chistov, I
    Pinelis, V
    Glusa, E
    THROMBOSIS AND HAEMOSTASIS, 1999, : 94 - 94
  • [28] Role of the aryl hydrocarbon receptor in cell cycle regulation
    Puga, A
    Marlowe, J
    Barnes, S
    Chang, CY
    Maier, A
    Tan, ZQ
    Kerzee, JK
    Chang, XQ
    Strobeck, M
    Knudsen, ES
    TOXICOLOGY, 2002, 181 : 171 - 177
  • [29] Role of the aryl hydrocarbon receptor in cell cycle regulation
    Puga, A
    TOXICOLOGY, 2001, 164 (1-3) : 13 - 13
  • [30] Dysregulation of T cell activation by the aryl hydrocarbon receptor
    Steppan, L
    Funatake, C
    Kerkvliet, N
    FASEB JOURNAL, 2004, 18 (05): : A815 - A815