Body mass index is negatively correlated with the response to controlled ovarian stimulation but does not influence oocyte morphology in ICSI cycles

被引：17
|
作者：
Setti, Amanda Souza [2 ]
de Almeida Ferreira Braga, Daniela Paes [1 ,2 ]
Savio Figueira, Rita de Cassia [1 ]
Vingris, Livia [1 ]
Iaconelli, Assumpto [1 ,2 ]
Borges, Edson, Jr. [1 ,2 ]
机构：
[1] Assisted Fertilizat Ctr, BR-01401002 Sao Paulo, Brazil
[2] Educ & Res Ctr Assisted Reprod, Sapientiae Inst, Sao Paulo, Brazil
来源：
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY | 2012年 / 163卷 / 02期
关键词：
Body mass index; Intracytoplasmic sperm injection; Oocyte; Oocyte morphology; Oocyte quality; INTRACYTOPLASMIC SPERM INJECTION; IN-VITRO FERTILIZATION; ASSISTED REPRODUCTION TREATMENT; EARLY-PREGNANCY LOSS; OVULATION INDUCTION; INFERTILE WOMEN; OBESE WOMEN; WEIGHT-LOSS; GONADOTROPIN; IMPACT;
D O I：
10.1016/j.ejogrb.2012.04.002
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Objective: To investigate whether or not body mass index (BMI) is associated with oocyte dysmorphisms. Study design: This retrospective study enrolled 1105 patients undergoing intracytoplasmic sperm injection (ICSI). The correlation between BMI and the response to controlled ovarian stimulation (COS) and ICSI outcomes was analysed. Oocyte morphology was determined in metaphase II (MII) oocytes retrieved from all cycles. The influence of BMI on the odds of having oocyte dysmorphism was also studied. Results: A negative correlation was found between BMI and the number of oocytes retrieved, MII oocytes, oocytes injected, embryos obtained, high-quality embryos and oocyte recovery rate. In addition, a trend towards a negative correlation between BMI and implantation rate was observed. However, BMI did not influence oocyte dysmorphisms. Conclusions: A negative correlation was found between BMI and the response to COS, and a trend towards a negative correlation was observed between BMI and implantation rate in the ICSI cycles. However, oocyte dysmorphisms were not influenced by BMI and, therefore, do not account for the reduced ICSI outcomes. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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收藏
页码：175 / 179
页数：5
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