The Role of PAI-1 and Adiponectin on the Inflammatory State and Energy Balance in Obese Adolescents with Metabolic Syndrome

被引：27
|
作者：
Corgosinho, Flavia Campos [1 ]
de Piano, Aline [1 ]
Sanches, Priscila L. [1 ]
Campos, Raquel M. [1 ]
Silva, Patricia L. [1 ]
Carnier, June [1 ]
Oyama, Lila M. [1 ]
Tock, Lian [1 ]
Tufik, Sergio [3 ]
de Mello, Marco T. [1 ,3 ]
Damaso, Ana R. [1 ,2 ]
机构：
[1] Univ Fed Sao Paulo, Postgrad Program Nutr, Paulista Med Sch, BR-11060001 Sao Paulo, Brazil
[2] Univ Fed Sao Paulo, Post Grad Program Interdisciplinary Hlth Sci, BR-04020050 Sao Paulo, Brazil
[3] Univ Fed Sao Paulo, Postgrad Program Psychobiol, Paulista Med Sch, BR-04020050 Sao Paulo, Brazil
来源：
INFLAMMATION | 2012年 / 35卷 / 03期
关键词：
PAI-1; interdisciplinary therapy; metabolic syndrome; energy balance; inflammation; adolescents; INSULIN-RESISTANCE; CHILDREN; WEIGHT; NEUROPEPTIDES; DISORDERS; BIOMARKER; LEPTIN;
D O I：
10.1007/s10753-011-9397-2
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Obesity is a chronic inflammatory disease and is considered a risk factor for metabolic syndrome. In this study, 57 obese adolescents with and without metabolic syndrome underwent 1 year of weight loss therapy. At baseline, the metabolic syndrome (MS) patients presented higher values of PAI-1 than the non-metabolic syndrome patients (n-MS). After therapy, significant improvements in anthropometrics and biochemical, inflammatory, and neuroendocrine variables were observed in both groups. However, the n-MS group presented better results than the MS group. Indeed, we found positive correlations in both groups between PAI-1 and neuropeptide Y (NPY) and between PAI-1 and NPY/AgRP. Inflammatory biomarkers may thus play a role in energy balance. The clinical trial registration number is NCT01358773.
引用
收藏
页码：944 / 951
页数：8
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