The Role of PAI-1 and Adiponectin on the Inflammatory State and Energy Balance in Obese Adolescents with Metabolic Syndrome

被引：27

作者：

Corgosinho, Flavia Campos ^{[1
]}

de Piano, Aline ^{[1
]}

Sanches, Priscila L. ^{[1
]}

Campos, Raquel M. ^{[1
]}

Silva, Patricia L. ^{[1
]}

Carnier, June ^{[1
]}

Oyama, Lila M. ^{[1
]}

Tock, Lian ^{[1
]}

Tufik, Sergio ^{[3
]}

de Mello, Marco T. ^{[1
,3
]}

Damaso, Ana R. ^{[1
,2
]}

机构：

[1] Univ Fed Sao Paulo, Postgrad Program Nutr, Paulista Med Sch, BR-11060001 Sao Paulo, Brazil

[2] Univ Fed Sao Paulo, Post Grad Program Interdisciplinary Hlth Sci, BR-04020050 Sao Paulo, Brazil

[3] Univ Fed Sao Paulo, Postgrad Program Psychobiol, Paulista Med Sch, BR-04020050 Sao Paulo, Brazil

来源：

INFLAMMATION | 2012年 / 35卷 / 03期

关键词：

PAI-1; interdisciplinary therapy; metabolic syndrome; energy balance; inflammation; adolescents; INSULIN-RESISTANCE; CHILDREN; WEIGHT; NEUROPEPTIDES; DISORDERS; BIOMARKER; LEPTIN;

D O I：

10.1007/s10753-011-9397-2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Obesity is a chronic inflammatory disease and is considered a risk factor for metabolic syndrome. In this study, 57 obese adolescents with and without metabolic syndrome underwent 1 year of weight loss therapy. At baseline, the metabolic syndrome (MS) patients presented higher values of PAI-1 than the non-metabolic syndrome patients (n-MS). After therapy, significant improvements in anthropometrics and biochemical, inflammatory, and neuroendocrine variables were observed in both groups. However, the n-MS group presented better results than the MS group. Indeed, we found positive correlations in both groups between PAI-1 and neuropeptide Y (NPY) and between PAI-1 and NPY/AgRP. Inflammatory biomarkers may thus play a role in energy balance. The clinical trial registration number is NCT01358773.

引用

页码：944 / 951

页数：8

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