Protective effects of silibinin on LPS-induced inflammation in human periodontal ligament cells

被引：2
作者：
Meng, Di [1 ]
Wang, Yuling [1 ,2 ]
Liu, Tongjun [1 ]
机构：
[1] Shandong First Med Univ, Dept Stomatol, Cent Hosp, Jinan, Peoples R China
[2] Shandong Qianfoshan Hosp, Dept Stomatol, Jinan, Peoples R China
来源：
FRONTIERS IN CHEMISTRY | 2022年 / 10卷
关键词：
silibinin; inflammation; protective effects; LPS-induced; human periodontal ligament cells; HEME OXYGENASE-1; STEM-CELLS; EXPRESSION; LIPOPOLYSACCHARIDE; INTERLEUKIN-1; GINGIVALIS; MECHANISMS;
D O I：
10.3389/fchem.2022.1019663
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Clinically, periodontitis is a chronic nonspecific inflammation that leads to damaged teeth and their supporting gum tissues. Although many studies on periodontitis have been conducted, therapy with natural products is still rare. Silibinin has been proven to have anti-inflammatory and antioxidant activities. However, the effects of silibinin on lipopolyssacharide (LPS)-induced inflammation in periodontal ligaments (PDLs) have not yet been investigated. In this study, the PDLs were treated with silibinin (10, 20, and 40 mu M) in the presence of LPS. The results showed that silibinin treatment reduced the levels of NO, PGE(2), IL-6, TNF-alpha, MMP-1, and MMP-3 and enhanced the activities of superoxide dismutase (SOD) and glutathione (GSH). Moreover, silibinin treatment downregulated RANKL levels and upregulated OPG and ALP levels. In summary, silibinin protected PDLs against LPS-induced inflammation, oxidative stress, and osteogenic differentiation.
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页数：8
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