Weight-Specific Anticipatory Coding of Grip Force in Human Dorsal Premotor Cortex

被引:32
作者
van Nuenen, Bart F. L. [1 ,2 ]
Kuhtz-Buschbeck, Johann [3 ]
Schulz, Christian [2 ]
Bloem, Bastiaan R. [1 ]
Siebner, Hartwig R. [2 ,4 ]
机构
[1] Radboud Univ Nijmegen, Med Ctr, Dept Neurol, Donders Inst Brain Cognit & Behav, NL-6500 HB Nijmegen, Netherlands
[2] Univ Kiel, Dept Neurol, D-2300 Kiel, Germany
[3] Univ Kiel, Dept Physiol, Kiel, Germany
[4] Univ Copenhagen, Hvidovre Hosp, Danish Res Ctr Magnet Resonance, DK-2650 Hvidovre, Denmark
关键词
TRANSCRANIAL MAGNETIC STIMULATION; THETA-BURST STIMULATION; SUPPLEMENTARY MOTOR AREA; CORTICOSPINAL EXCITABILITY; FUNCTIONAL-ORGANIZATION; FRONTAL-CORTEX; BRAIN ACTIVITY; MANIPULATION; MOVEMENTS; SELECTION;
D O I
10.1523/JNEUROSCI.5673-11.2012
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The dorsal premotor cortex (PMd) uses prior sensory information for motor preparation. Here, we used a conditioning-and-map approach in 11 healthy male humans (mean age 27 years) to further clarify the role of PMd in anticipatory motor control. We transiently disrupted neuronal processing in PMd, using either continuous theta burst stimulation (cTBS) at 80% (inhibitory cTBS) or 30% (sham cTBS) of active motor threshold. The conditioning effects of cTBS on preparatory brain activity were assessed with functional MRI, while participants lifted a light or heavy weight in response to a go-cue (S2). An additional pre-cue (S1) correctly predicted the weight in 75% of the trials. Participants were asked to use this prior information to prepare for the lift. In the sham condition, grip force showed a consistent undershoot, if the S1 incorrectly prompted the preparation of a light lift. Likewise, an S1 that falsely announced a heavy weight produced a consistent overshoot in grip force. In trials with incorrect S1, preparatory activity in left PMd during the S1-S2 delay period predicted grip force undershoot but not overshoot. Real cTBS selectively abolished this undershoot in grip force. Furthermore, preparatory S1-S2 activity in left PMd no longer predicted the individual undershoot after real cTBS. Our results provide converging evidence for a causal involvement of PMd in anticipatory downscaling but not upscaling of grip force, suggesting an inhibitory role of PMd in anticipatory grip force control during object lifting.
引用
收藏
页码:5272 / 5283
页数:12
相关论文
共 44 条
  • [1] Local morphology predicts functional organization of the dorsal premotor region in the human brain
    Amiez, C
    Kostopoulos, P
    Champod, AS
    Petrides, M
    [J]. JOURNAL OF NEUROSCIENCE, 2006, 26 (10) : 2724 - 2731
  • [2] Astafiev SV, 2003, J NEUROSCI, V23, P4689
  • [3] Attention versus intention in the primate premotor cortex
    Boussaoud, D
    [J]. NEUROIMAGE, 2001, 14 (01) : S40 - S45
  • [4] Modulating neural networks with transcranial magnetic stimulation applied over the dorsal premotor and primary motor cortices
    Chouinard, PA
    Van der Werf, YD
    Leonard, G
    Paus, T
    [J]. JOURNAL OF NEUROPHYSIOLOGY, 2003, 90 (02) : 1071 - 1083
  • [5] Role of the primary motor and dorsal premotor cortices in the anticipation of forces during object lifting
    Chouinard, PA
    Leonard, G
    Paus, T
    [J]. JOURNAL OF NEUROSCIENCE, 2005, 25 (09) : 2277 - 2284
  • [6] Premotor cortex modulates somatosensory cortex during voluntary movements without proprioceptive feedback
    Christensen, Mark Schram
    Lundbye-Jensen, Jesper
    Geertsen, Svend Sparre
    Petersen, Tue Hvass
    Paulson, Olaf B.
    Nielsen, Jens Bo
    [J]. NATURE NEUROSCIENCE, 2007, 10 (04) : 417 - 419
  • [7] Old age impairs the use of arbitrary visual cues for predictive control of fingertip forces during grasp
    Cole, KJ
    Rotella, DL
    [J]. EXPERIMENTAL BRAIN RESEARCH, 2002, 143 (01) : 35 - 41
  • [8] Neural Correlates of Preparation for Action Selection as a Function of Specific Task Demands
    Donohue, S. E.
    Wendelken, C.
    Bunge, Silvia A.
    [J]. JOURNAL OF COGNITIVE NEUROSCIENCE, 2008, 20 (04) : 694 - 706
  • [9] Differential fronto-parietal activation depending on force used in a precision grip task: An fMRI study
    Ehrsson, HH
    Fagergren, A
    Forssberg, H
    [J]. JOURNAL OF NEUROPHYSIOLOGY, 2001, 85 (06) : 2613 - 2623
  • [10] Control strategies in object manipulation tasks
    Flanagan, J. Randall
    Bowman, Miles C.
    Johansson, Roland S.
    [J]. CURRENT OPINION IN NEUROBIOLOGY, 2006, 16 (06) : 650 - 659