Systemic immune-inflammation index predicts prognosis in patients with epithelial ovarian cancer: A retrospective study

被引：77

作者：

Nie, Dan ^{[1
,2
]}

Gong, Han ^{[1
]}

Mao, Xiguang ^{[2
]}

Li, Zhengyu ^{[1
]}

机构：

[1] Sichuan Univ, Dept Obstet & Gynecol, Key Lab Birth Defects & Related Dis Women & Child, Minist Educ,West China Univ Hosp 2, Chengdu 610041, Sichuan, Peoples R China

[2] Southwest Med Univ, Dept Obstet & Gynecol, Affiliated Hosp, Luzhou 646000, Peoples R China

来源：

GYNECOLOGIC ONCOLOGY | 2019年 / 152卷 / 02期

关键词：

Systemic immune-inflammation index; Ovarian cancer; Prognosis; LYMPHOCYTE RATIO; PLATELET/LYMPHOCYTE RATIO; PLATELET; NEUTROPHIL;

D O I：

10.1016/j.ygyno.2018.11.034

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Objective. The study aimed to investigate the prognostic value of the systemic immune-inflammation index (SII) in patients with epithelial ovarian cancer (EOC). Methods. A total of 553 EOC patients were retrospectively analyzed. 250 patients from West China Second University Hospital were assigned into the discovery cohort and 283 patients from The Affiliated Hospital of Southwest Medical University were assigned into the validation cohort. The correlation between SII and survival were analyzed using Cox regression analyses and Kaplan-Meier method. Prediction accuracy was evaluated with the receiver operating characteristics (ROC) curve. Results. The high SII ( >= 612) was correlated with advanced FIGO stage, lymph node metastasis, and tumor recurrence. In univariate Cox regression, patients with high SII ( >= 612) had a significantly shorter progression-free survival (PFS) and overall survival (OS) compared to low SII patients ( <612) in both cohorts. In multivariate Cox regression analysis, SII was an independent prognostic indicator for PFS (HR = 7.61, 95% CI 3.34-17.35, P < 0.001) and OS (HR = 6.36, 95% CI 2.64-15.33, P < 0.001) in the discovery cohort. These results were verified in the validation cohort. Conclusion. High SII was correlated with poor survival in patients with EOC. The SII was an independent prognostic factor for patients with EOC. (C) 2018 Elsevier Inc. All rights reserved.

引用

页码：259 / 264

页数：6

共 28 条

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