5-Alkylidenethiophen-2(5H)-ones as Biofilm Inhibitors

被引：1

作者：

Benneche, Tore ^{[1
]}

Chamgordani, Elahe Jafari ^{[1
]}

Herstad, Gunnar ^{[1
]}

Tannaes, Bjorg Siw Moller ^{[2
]}

Scheie, Anne Aamdal ^{[3
]}

机构：

[1] Univ Oslo, Dept Chem, Oslo, Norway

[2] Oslo & Akershus Univ, Coll Appl Sci, Oslo, Norway

[3] Univ Oslo, Dept Oral Biol, Oslo, Norway

来源：

LETTERS IN ORGANIC CHEMISTRY | 2016年 / 13卷 / 06期

关键词：

5-alkylidenethiophen-2(5H)-ones; biofilm inhibition; quorum sensing; synthesis; VIBRIO-HARVEYI; FURANONE;

D O I：

10.2174/1570178613666160620114658

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A number of thiophen-2(5H)-ones with different substituents in the 3-, 4- and 5-position have been synthesized and tested as inhibitors of biofilm production by the marine bacterium Vibrio harveyi BB120. Concentrations that inhibited 50% or 90% of biofilm formation (BIC50, BIC90) and of plantonic growth (PIC50, PIC90) are reported.

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收藏

页码：428 / 436

页数：9

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