Graphene-Based High-Efficiency Surface-Enhanced Raman Scattering-Active Platform for Sensitive and Multiplex DNA Detection

被引：183

作者：

He, Shijiang ^{[1
]}

Liu, Keng-Ku ^{[2
]}

Su, Shao ^{[1
]}

Yan, Juan ^{[1
]}

Mao, Xiuhai ^{[1
]}

Wang, Dongfang ^{[1
]}

He, Yao ^{[3
,4
]}

Li, Lain-Jong ^{[2
]}

Song, Shiping ^{[1
]}

Fan, Chunhai ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Appl Phys, Phys Biol Lab, Shanghai 201800, Peoples R China

[2] Acad Sinica, Inst Atom & Mol Sci, Taipei 11529, Taiwan

[3] Soochow Univ, Inst Funct Nano & Soft Mat FUNSOM, Suzhou 215123, Jiangsu, Peoples R China

[4] Soochow Univ, Jiangsu Key Lab Carbon Based Funct Mat & Devices, Suzhou 215123, Jiangsu, Peoples R China

来源：

ANALYTICAL CHEMISTRY | 2012年 / 84卷 / 10期

基金：

美国国家科学基金会;

关键词：

SENSING BIOMOLECULES; SILVER NANOPARTICLES; SINGLE; SPECTROSCOPY; OXIDE; GOLD; MOLECULES; SUBSTRATE;

D O I：

10.1021/ac300577d

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

We have developed a surface-enhanced Raman scattering (SERS)-active substrate based on gold nanoparticle-decorated chemical vapor deposition (CVD)-growth graphene and used it for multiplexing detection of DNA. Due to the combination of gold nanoparticles and graphene, the Raman signals of dye were dramatically enhanced by this novel substrate. With the gold nanoparticles, DNA capture probes could be easily assembled on the surface of graphene films which have a drawback to directly immobilize DNA. This platform exhibits extraordinarily high sensitivity and excellent specificity for DNA detection. A detection limit as low as 10 pM is obtained. Importantly, two different DNA targets could be detected simultaneously on the same substrate just using one light source.

引用

页码：4622 / 4627

页数：6

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