Synthesis and utilization of functionalized polystyrene resins

被引：50
作者：
Thomas, GL
Böhner, C
Ladlow, M
Spring, DR
机构：
[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England
[2] Univ Cambridge, GSK Cambridge Technol Ctr, Cambridge, England
来源：
TETRAHEDRON | 2005年 / 61卷 / 51期
基金：
英国生物技术与生命科学研究理事会;
关键词：
polystyrene; triphenylphosphine; polymer-supported synthesis; metallation;
D O I：
10.1016/j.tet.2005.07.118
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Co-polymerised 4-bromopolystyrene has been converted to a range of polymer-supported reagents and scavengers by bromine-magnesium exchange using Oshima's trialkylmagnesate complex followed by quenching with a variety of electrophiles. Mitsunobu, halogenation and Wittig reactions, were explored to assess the utility of the resins for target oriented and diversity oriented synthesis. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：12153 / 12159
页数：7
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