Effect of a contralateral lesion on neurological recovery from stroke in rats

被引：14

作者：

Sun, Fen ^{[1
]}

Xie, Lin ^{[1
]}

Mao, XiaoOu ^{[1
]}

Hill, Justin ^{[1
]}

Greenberg, David A. ^{[1
]}

Jin, Kunlin ^{[1
]}

机构：

[1] Univ N Texas, Hlth Sci Ctr, Dept Pharmacol & Neurosci, Ft Worth, TX 76107 USA

来源：

RESTORATIVE NEUROLOGY AND NEUROSCIENCE | 2012年 / 30卷 / 06期

关键词：

Stroke; ischemia; recovery; rat; NONINVASIVE BRAIN-STIMULATION; CORPUS-CALLOSUM; INTERHEMISPHERIC INTERACTIONS; BEHAVIORAL RECOVERY; MOTOR FUNCTION; CORTEX; INHIBITION; FORELIMB; INFARCTS; DEFICITS;

D O I：

10.3233/RNN-2012-120254

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Purpose: Clinical studies suggest a correlation between changes in activity of the contralesional cerebral cortex and spontaneous recovery from stroke, but whether this is a causal relationship is uncertain. Methods: Young adult Sprague-Dawley male rats underwent unilateral or bilateral permanent distal middle cerebral artery occlusion (dMCAO). Infarct volume was determined by 2,3,5-triphenyltetrazolium chloride (TTC) staining 24 hr after dMCAO, and functional outcome was assessed 1-28 days after dMCAO using the ladder rung walking and limb placing tests. Results: Infarct volume was unchanged, but functional neurological deficits were reduced 1 day after bilateral compared to unilateral dMCAO. Conclusions: Activity in the contralesional cerebral cortex may inhibit functional motor recovery acutely after experimental stroke.

引用

页码：491 / 495

页数：5

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