Bakkenolides from Petasites tricholobus and Their Neuroprotective Effects Related to Antioxidant Activities

被引：33

作者：

Wang, Yu-Liang ^{[1
,2
]}

Li, Run-Ping ^{[3
]}

Guo, Mei-Li ^{[1
]}

Zhang, Ge ^{[1
]}

Zhang, Na ^{[1
]}

Ma, Yan-Li ^{[1
]}

机构：

[1] Second Mil Med Univ, Dept Pharmacognosy, Sch Pharm, Shanghai 200433, Peoples R China

[2] Shanghai Jiao Tong Univ, Plant Biotechnol Res Ctr, Sch Agr & Biol, Shanghai 200030, Peoples R China

[3] Second Mil Med Univ, Dept Diving Med, Fac Naval Med, Shanghai 200433, Peoples R China

来源：

PLANTA MEDICA | 2009年 / 75卷 / 03期

关键词：

Petasites tricholobus; Asteraceae; bakkenolide; neuroprotection; JAPONICUS MAXIM; SESQUITERPENES; DERIVATIVES; FORMOSANUS; RHIZOMES; NEURONS; ROOT;

D O I：

10.1055/s-0028-1088377

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Four novel bakkenolides - bakkenolide-Ia (1), bakkenolide-IIa (2), bakkenolide-IIIa (3) and bakkenolide-IVa (4) - were isolated from the extract of the rhizome of Petasites tricholobus. The structures were characterized by using NMR (H-1, C-13, H-1-H-1 COSY, HMQC, HMBC, and NOESY) and mass spectrometry. The neuroprotective activity of the compounds 1-4 was assayed with primary cultured neurons exposed to oxygen-glucose deprivation and oxidative insults. Antioxidant activity of the bakkenolides was evaluated by cell-free bioassays. The in vitro assay results showed that all these compounds exhibited significant neuroprotective and antioxidant activities. To our knowledge, this is the first report on the neuroprotective and antioxidant activities of bakkenolides.

引用

页码：230 / 235

页数：6

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