Antioxidant and hemolytic activities, and effects in rat cutaneous wound healing of a novel polysaccharide from fenugreek (Trigonella foenum-graecum) seeds

被引：59

作者：

Ktari, Naourez ^{[1
]}

Trabelsi, Imen ^{[2
]}

Bardaa, Sana ^{[3
]}

Triki, Mehdi ^{[2
]}

Bkhairia, Intidhar ^{[1
,2
]}

Ben Slama-Ben Salem, Rabab ^{[1
]}

Nasri, Moncef ^{[1
]}

Ben Salah, Riadh ^{[2
]}

机构：

[1] Univ Sfax, Natl Sch Engn Sfax, Lab Enzyme Engn & Microbiol, POB 1173-3038, Sfax, Tunisia

[2] Ctr Biotechnol Sfax, Lab Microorganisms & Biomol LMB, Rd Sidi Mansour Km 6,POB 1177, Sfax 3018, Tunisia

[3] Univ Sfax, Fac Med Sfax, Pharmacol Lab, Ave Majida Boulila, Sfax 3029, Tunisia

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2017年 / 95卷

关键词：

Polysaccharide; Fenugreek seeds; Antioxidant activities; Hemolytic activity; Wound healing; WATER-SOLUBLE POLYSACCHARIDES; CHEMICAL-COMPOSITION; ASSISTED EXTRACTION; IN-VITRO; OPTIMIZATION; SALICYLATE;

D O I：

10.1016/j.ijbiomac.2016.11.091

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The aim of this work was to evaluate the antioxidant and hemolytic activities as well as the in vivo wound healing performance of a novel polysaccharide (FWEP) extracted from fenugreek (Trigonella foenumgraecum) seeds. The antioxidant activity was evaluated in vivo and in vitro using various assays. Results showed that FWEP exhibited strong antioxidant activities but no hemolytic activity was observed towards bovine erythrocytes. The application of FWEP hydrogel on the wound site in a rat model enhanced significantly wound healing activity and accelerated the wound closure after 14 days of wound induction. Histological examination also demonstrated fully re-epithelialized wound with a complete epidermal regeneration. Altogether, these evidences demonstrated that FWEP had strong wound healing potential presumably achieved through its antioxidant activities. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：625 / 634

页数：10