Transition-metal-free synthesis of multisubstituted N-arylindoles via reaction of arynes and α-amino ketones

被引：28

作者：

He, Lin ^{[1
]}

Pian, Ji-Xin ^{[1
]}

Shi, Jun-Feng ^{[1
]}

Du, Guang-Fen ^{[1
]}

Dai, Bin ^{[1
]}

机构：

[1] Shihezi Univ, Sch Chem & Chem Engn, Key Lab Green Proc Chem Engn Xinjiang Bingtuan, Shihezi 832000, Xinjiang Uygur, Peoples R China

来源：

TETRAHEDRON | 2014年 / 70卷 / 14期

基金：

中国国家自然科学基金;

关键词：

Indoles; Arynes; Cross-coupling reaction; alpha-Amino ketones; SIMPLE INDOLE ALKALOIDS; EFFICIENT SYNTHESIS; OXIDATIVE CYCLIZATION; BOND; BENZYNE; CONSTRUCTION; AMINATION; ARYLATION; CASCADE;

D O I：

10.1016/j.tet.2014.02.028

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple transition-metal-free protocol for the synthesis of indoles has been developed using aryne cycloaddition. The in situ-generated arynes couple with alpha-amino ketones through a one-step N-arylation-nucleophilic addition process under mild conditions and efficiently produce multi-substituted N-arylindoles. (C) 2014 Elsevier Ltd. All rights reserved.

引用

收藏

页码：2400 / 2405

页数：6

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