Critical Analysis of a Challenging Case of Post-Infectious N-Methyl-D-Aspartate Receptor Encephalitis

被引：0

作者：

Epstein, Samantha ^{[1
]}

Ankam, Jyoti ^{[2
]}

Vargas, Wendy S. ^{[1
,3
]}

Thakur, Kiran T. ^{[1
]}

机构：

[1] Columbia Univ, Irving Med Ctr, Dept Neurol, New York, NY 10023 USA

[2] Columbia Univ, Mailman Sch Publ Hlth, Dept Biostat & Adv Epidemiol, New York, NY 10023 USA

[3] Columbia Univ, Med Ctr, Dept Pediat Neurol, New York, NY 10023 USA

来源：

NEUROHOSPITALIST | 2021年 / 11卷 / 02期

关键词：

autoimmune diseases of the nervous system; central nervous system viral diseases; central nervous system infections; encephalitis; neuroimmunology; clinical specialty;

D O I：

10.1177/1941874420964356

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Infections are increasingly recognized as a common trigger of autoimmune disease, including autoimmune encephalitis. A significant association is particularly shown between HSV-I encephalitis (HSVE) and a post-infectious autoimmune encephalitis mediated by neuronal autoantibodies, most notably anti-N-methyl-D-aspartate receptor (NMDAR) antibodies. The clinical significance of these and other novel post-infectious autoantibodies has led to new diagnostic and treatment challenges for clinicians. Here we present a case of a 19-year-old female with premorbid psychiatric disease and neuropsychiatric sequelae from HSVE who presented over a year after her initial HSVE with behavioral changes and positive anti-NMDAR antibodies. The clinical challenges encountered during this case are explored in detail based on a review of the literature. Research is needed to help guide management in these complex clinical situations.

引用

页码：160 / 164

页数：5

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