Structural elucidation, total synthesis, and cytotoxic activity of effphenol A

被引：12

作者：

Liu, Hongxin ^{[1
]}

Chen, Shanchong ^{[1
]}

Zhang, Xiao ^{[2
]}

Dong, Chunmao ^{[2
,3
]}

Chen, Yuchan ^{[1
]}

Liu, Zhaoming ^{[1
]}

Tan, Haibo ^{[2
,3
]}

Zhang, Weimin ^{[1
]}

机构：

[1] Guangdong Acad Sci, Guangdong Prov Key Lab Microbial Culture Collect, State Key Lab Appl Microbiol Southern China, Guangdong Open Lab Appl Microbiol,Guangdong Inst, Guangzhou 510070, Peoples R China

[2] Chinese Acad Sci, Key Lab Plant Resources Conservat & Sustainable U, Guangdong Prov Key Lab Appl Bot, Program Nat Prod Chem Biol,South China Bot Garden, Guangzhou 510650, Peoples R China

[3] Cent South Univ, Xiangya Sch Pharmaceut Sci, Changsha 410013, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2020年 / 18卷 / 44期

基金：

中国国家自然科学基金;

关键词：

NATURAL-PRODUCTS; MEROTERPENOIDS; DERIVATIVES;

D O I：

10.1039/d0ob01985b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly substituted phenol derivative, effphenol A (1), was isolated from the deep-sea-derived fungus Trichobotrys effuse FS524. Its complete structural assignment was established through a combination of spectroscopic analysis together with single-crystal X-ray diffraction experiments and further unequivocally confirmed by a biomimetic total synthesis. Structurally, effphenol A possesses a poly-substituted 6-5/6/6 tetracyclic ring system, which represents the first case of such a skeleton found in nature. Furthermore, the cytotoxic activity of effphenol A (1) toward four human cancer cell lines was assayed.

引用

页码：9035 / 9038

页数：4

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