Photodynamic Activity C70 Caged within Surface-Cross-Linked Liposomes

被引：34

作者：

Ikeda, Atsushi ^{[1
]}

Nagano, Mai ^{[1
]}

Akiyama, Motofusa ^{[1
]}

Matsumoto, Masashi ^{[1
]}

Ito, Sayuri ^{[1
]}

Mukai, Masaru ^{[1
]}

Hashizume, Mineo ^{[1
]}

Kikuchi, Jun-ichi ^{[1
]}

Katagiri, Kiyofumi ^{[2
]}

Ogawa, Takuya ^{[3
]}

Takeya, Tatsuo ^{[3
]}

机构：

[1] Nara Inst Sci & Technol, Grad Sch Mat Sci, Nara 6300192, Japan

[2] Nagoya Univ, Grad Sch Engn, Chikusa Ku, Nagoya, Aichi 4648603, Japan

[3] Nara Inst Sci & Technol, Grad Sch Biol Sci, Nara 6300192, Japan

来源：

CHEMISTRY-AN ASIAN JOURNAL | 2009年 / 4卷 / 01期

基金：

日本学术振兴会;

关键词：

cyclodextrins; exchange reactions; fullerenes; lipid bilayers; photodynamic activities; MACROMOLECULAR THERAPEUTICS; CERASOME; THERAPY; MEMBRANE; SOLUBILIZATION; PHOTOCLEAVAGE; CYCLODEXTRIN; AGENT;

D O I：

10.1002/asia.200800271

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

[70]Fullerene (C-70) encapsulated into a surface-cross-linked liposome, a so-called cerasome, was prepared by an exchange reaction incorporating C70 center dot gamma-cyclodextrin complexes into lipid membranes, Fullerene exchange in a cerasome-incorporated C-70 (CIC70), as well as in a lipid-membrane-incorporated C-70 (LMIC70), was completed within 1 min with stirring at 25 degrees C. CIC70 was more resistant to lysis than LMIC70 towards lysing agents such as surfactants. Furthermore, the photodynamic activity of CIC70 in HeLa cells was similar to that of LMIC70, indicating that C-70 can act as a photosensitizing drug (PS) without release from cerasome membranes. Thus, in contrast with general drug-delivery systems (DDSs), which require the drug to be released from the interior of liposomes, carriers for PSs for use in photodynamic therapy (PDT) do not necessarily need to release the drug. These results indicate that DDSs with high morphological stability can increase the residence time in blood and achieves tumor-selective drug delivery by the enhanced permeability and retention (EPR) effect.

引用

页码：199 / 205

页数：7

共 30 条

[1] Solubilisation of [60]fullerenes using block copolymers and evaluation of their photodynamic activities [J].