Potential Role of Lycopene in the Treatment of Hepatitis C and Prevention of Hepatocellular Carcinoma

被引：15
作者：
Seren, Soley [1 ]
Mutchnick, Milton [1 ,2 ]
Hutchinson, Daryl [1 ,2 ]
Harmanci, Ozgur [3 ]
Bayraktar, Yusuf [3 ]
Mutchnick, Sean [1 ,2 ]
Sahin, Kazim [4 ]
Kucuk, Omer [1 ,5 ,6 ]
机构：
[1] Wayne State Univ, Dept Med, Detroit, MI 48202 USA
[2] Wayne State Univ, Div Gastroenterol, Detroit, MI USA
[3] Hacettepe Univ, Dept Med, Div Gastroenterol, Ankara, Turkey
[4] Firat Univ, Fac Vet Sci, Dept Anim Nutr, TR-23169 Elazig, Turkey
[5] Wayne State Univ, Div Hematol & Oncol, Detroit, MI USA
[6] Barbara Ann Karmanos Canc Inst, Detroit, MI USA
来源：
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL | 2008年 / 60卷 / 06期
关键词：
D O I：
10.1080/01635580802419772
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Hepatitis C virus (HCV) infection and hepatocellular carcinoma (HCC) are growing health problems around the world. Oxidative stress plays a significant role in the initiation and progression of hepatocellular damage and possibly in the development of HCC in HCV infected patients. In vitro, animal and clinical studies suggest that lycopene, a nonprovitamin A carotenoid and a potent antioxidant, may attenuate the liver injury and possibly prevent the development of HCC. In this article, we discuss the relationship between HCV infection and oxidative stress and review the potential role of lycopene in the treatment of HCV and prevention of HCC.
引用
收藏
页码：729 / 735
页数：7
相关论文
共 70 条
  • [1] The prevalence of hepatitis C virus infection in the United States, 1988 through 1994
    Alter, MJ
    Kruszon-Moran, D
    Nainan, OV
    McQuillan, GM
    Gao, FX
    Moyer, LA
    Kaslow, RA
    Margolis, HS
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1999, 341 (08) : 556 - 562
  • [2] *AM CANC SOC, 2004, CANC FACTS FIG 2004, V60
  • [3] Dietary lycopene decreases the initiation of liver preneoplastic foci by diethylnitrosamine in the rat
    Astorg, P
    Gradelet, S
    Berges, R
    Suschetet, M
    [J]. NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 1997, 29 (01): : 60 - 68
  • [4] AUST S D, 1985, Journal of Free Radicals in Biology and Medicine, V1, P3, DOI 10.1016/0748-5514(85)90025-X
  • [5] Beck MA, 2003, J NUTR, V133, p1463S, DOI 10.1093/jn/133.5.1463S
  • [6] N-ACETYL CYSTEINE ENHANCES THE RESPONSE TO INTERFERON-ALPHA IN CHRONIC HEPATITIS-C - A PILOT-STUDY
    BELOQUI, O
    PRIETO, J
    SUAREZ, M
    GIL, B
    QIAN, CH
    GARCIA, N
    CIVEIRA, MP
    [J]. JOURNAL OF INTERFERON RESEARCH, 1993, 13 (04): : 279 - 282
  • [7] DIVERSE CAROTENOIDS PROTECT AGAINST CHEMICALLY-INDUCED NEOPLASTIC TRANSFORMATION
    BERTRAM, JS
    PUNG, A
    CHURLEY, M
    KAPPOCK, TJ
    WILKINS, LR
    COONEY, RV
    [J]. CARCINOGENESIS, 1991, 12 (04) : 671 - 678
  • [8] Iron and chronic viral hepatitis
    Bonkovsky, HL
    Banner, BF
    Rothman, AL
    [J]. HEPATOLOGY, 1997, 25 (03) : 759 - 768
  • [9] BRIENHOLT V, 2004, CANC LETT, V154, P201
  • [10] Nonstructural 3 protein of hepatitis C virus triggers an oxidative burst in human monocytes via activation of NADPH oxidase
    Bureau, C
    Bernad, J
    Chaouche, N
    Orfila, C
    Béraud, M
    Gonindard, C
    Alric, L
    Vinel, JP
    Pipy, B
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (25) : 23077 - 23083
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