Di-(2-ethylhexyl) phthalate (DEHP) is used to increase the flexibility of plastics for industrial products. However, the illegal use of the plasticizer DEHP in food and drinks has been reported in Taiwan in 2011. In order to assess the exact extent of the absorption of DEHP via the oral route, the aim of this study is to develop a reliable and validated ultra performance liquid chromatography with tandem mass spectrometry (UPLC-MS/MS) method to evaluate the oral bioavailability of DEHP in rats. The optimal chromatographic separation of DEHP and butyl benzyl phthalate (BBP; used as internal standard) were achieved on a C-18 column. The mobile phase was consisted of 5 mM ammonium acetate-methanol (11:89, v/v) with a flow rate of 0.25 mL/min. The monitoring ion transitions were m/z 391.4 -> 149.0 for DEHP and m/z 313.3 -> 149.0 for BBP. The mean matrix effects of DEHP at low, medium and high concentrations were 94.5 +/- 5.7% and 100.1 +/- 2.3% in plasma and feces homogenate samples, respectively. In conclusion, the validated UPLC-MS/MS method is suitable for analyzing the rat plasma sample of DEHP and the oral bioavailability of DEHP was about 7% in rats.
机构:
Univ Lille Nord France, Dept Biopharm Galen & Hosp Pharm, IFR114, EA 4481, F-59000 Lille, FranceUniv Lille Nord France, Dept Biopharm Galen & Hosp Pharm, IFR114, EA 4481, F-59000 Lille, France
Genay, Stephanie
;
Luciani, Chiara
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机构:
Univ Lille Nord France, Dept Biopharm Galen & Hosp Pharm, IFR114, EA 4481, F-59000 Lille, France
Univ Camerino, Dept Chem Sci, I-62032 Camerino, ItalyUniv Lille Nord France, Dept Biopharm Galen & Hosp Pharm, IFR114, EA 4481, F-59000 Lille, France
Luciani, Chiara
;
Decaudin, Bertrand
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机构:
Univ Lille Nord France, Dept Biopharm Galen & Hosp Pharm, IFR114, EA 4481, F-59000 Lille, France
CHU Lille, Reg Univ Hosp Lille, Dept Pharm, F-59000 Lille, FranceUniv Lille Nord France, Dept Biopharm Galen & Hosp Pharm, IFR114, EA 4481, F-59000 Lille, France
Decaudin, Bertrand
;
Kambia, Nicolas
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h-index: 0
机构:
Univ Lille Nord France, Dept Pharmacol Pharmacokinet & Clin Pharm, IFR114, EA 4481, F-59000 Lille, FranceUniv Lille Nord France, Dept Biopharm Galen & Hosp Pharm, IFR114, EA 4481, F-59000 Lille, France
Kambia, Nicolas
;
Dine, Thierry
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h-index: 0
机构:
Univ Lille Nord France, Dept Pharmacol Pharmacokinet & Clin Pharm, IFR114, EA 4481, F-59000 Lille, FranceUniv Lille Nord France, Dept Biopharm Galen & Hosp Pharm, IFR114, EA 4481, F-59000 Lille, France
Dine, Thierry
;
Azaroual, Nathalie
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h-index: 0
机构:
Univ Lille Nord France, Dept Phys, IFR114, EA 4481, F-59000 Lille, FranceUniv Lille Nord France, Dept Biopharm Galen & Hosp Pharm, IFR114, EA 4481, F-59000 Lille, France
Azaroual, Nathalie
;
Di Martino, Piera
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机构:
Univ Camerino, Dept Chem Sci, I-62032 Camerino, ItalyUniv Lille Nord France, Dept Biopharm Galen & Hosp Pharm, IFR114, EA 4481, F-59000 Lille, France
Di Martino, Piera
;
Barthelemy, Christine
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机构:
Univ Lille Nord France, Dept Biopharm Galen & Hosp Pharm, IFR114, EA 4481, F-59000 Lille, FranceUniv Lille Nord France, Dept Biopharm Galen & Hosp Pharm, IFR114, EA 4481, F-59000 Lille, France
Barthelemy, Christine
;
Odou, Pascal
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机构:
Univ Lille Nord France, Dept Biopharm Galen & Hosp Pharm, IFR114, EA 4481, F-59000 Lille, France
CHU Lille, Reg Univ Hosp Lille, Dept Pharm, F-59000 Lille, FranceUniv Lille Nord France, Dept Biopharm Galen & Hosp Pharm, IFR114, EA 4481, F-59000 Lille, France
机构:
Hoshi Univ, Fac Pharmaceut Sci, Dept Analyt Chem, Shinagawa Ku, 2-4-41 Ebara, Tokyo 1428501, JapanHoshi Univ, Fac Pharmaceut Sci, Dept Analyt Chem, Shinagawa Ku, 2-4-41 Ebara, Tokyo 1428501, Japan
Inoue, K
;
Kawaguchi, M
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机构:
Hoshi Univ, Fac Pharmaceut Sci, Dept Analyt Chem, Shinagawa Ku, 2-4-41 Ebara, Tokyo 1428501, JapanHoshi Univ, Fac Pharmaceut Sci, Dept Analyt Chem, Shinagawa Ku, 2-4-41 Ebara, Tokyo 1428501, Japan
Kawaguchi, M
;
Okada, F
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机构:
Hoshi Univ, Fac Pharmaceut Sci, Dept Analyt Chem, Shinagawa Ku, 2-4-41 Ebara, Tokyo 1428501, JapanHoshi Univ, Fac Pharmaceut Sci, Dept Analyt Chem, Shinagawa Ku, 2-4-41 Ebara, Tokyo 1428501, Japan
Okada, F
;
Yoshimura, Y
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Hoshi Univ, Fac Pharmaceut Sci, Dept Analyt Chem, Shinagawa Ku, 2-4-41 Ebara, Tokyo 1428501, JapanHoshi Univ, Fac Pharmaceut Sci, Dept Analyt Chem, Shinagawa Ku, 2-4-41 Ebara, Tokyo 1428501, Japan
Yoshimura, Y
;
Nakazawa, H
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h-index: 0
机构:
Hoshi Univ, Fac Pharmaceut Sci, Dept Analyt Chem, Shinagawa Ku, 2-4-41 Ebara, Tokyo 1428501, JapanHoshi Univ, Fac Pharmaceut Sci, Dept Analyt Chem, Shinagawa Ku, 2-4-41 Ebara, Tokyo 1428501, Japan
机构:
Univ Lille Nord France, Dept Biopharm Galen & Hosp Pharm, IFR114, EA 4481, F-59000 Lille, FranceUniv Lille Nord France, Dept Biopharm Galen & Hosp Pharm, IFR114, EA 4481, F-59000 Lille, France
Genay, Stephanie
;
Luciani, Chiara
论文数: 0引用数: 0
h-index: 0
机构:
Univ Lille Nord France, Dept Biopharm Galen & Hosp Pharm, IFR114, EA 4481, F-59000 Lille, France
Univ Camerino, Dept Chem Sci, I-62032 Camerino, ItalyUniv Lille Nord France, Dept Biopharm Galen & Hosp Pharm, IFR114, EA 4481, F-59000 Lille, France
Luciani, Chiara
;
Decaudin, Bertrand
论文数: 0引用数: 0
h-index: 0
机构:
Univ Lille Nord France, Dept Biopharm Galen & Hosp Pharm, IFR114, EA 4481, F-59000 Lille, France
CHU Lille, Reg Univ Hosp Lille, Dept Pharm, F-59000 Lille, FranceUniv Lille Nord France, Dept Biopharm Galen & Hosp Pharm, IFR114, EA 4481, F-59000 Lille, France
Decaudin, Bertrand
;
Kambia, Nicolas
论文数: 0引用数: 0
h-index: 0
机构:
Univ Lille Nord France, Dept Pharmacol Pharmacokinet & Clin Pharm, IFR114, EA 4481, F-59000 Lille, FranceUniv Lille Nord France, Dept Biopharm Galen & Hosp Pharm, IFR114, EA 4481, F-59000 Lille, France
Kambia, Nicolas
;
Dine, Thierry
论文数: 0引用数: 0
h-index: 0
机构:
Univ Lille Nord France, Dept Pharmacol Pharmacokinet & Clin Pharm, IFR114, EA 4481, F-59000 Lille, FranceUniv Lille Nord France, Dept Biopharm Galen & Hosp Pharm, IFR114, EA 4481, F-59000 Lille, France
Dine, Thierry
;
Azaroual, Nathalie
论文数: 0引用数: 0
h-index: 0
机构:
Univ Lille Nord France, Dept Phys, IFR114, EA 4481, F-59000 Lille, FranceUniv Lille Nord France, Dept Biopharm Galen & Hosp Pharm, IFR114, EA 4481, F-59000 Lille, France
Azaroual, Nathalie
;
Di Martino, Piera
论文数: 0引用数: 0
h-index: 0
机构:
Univ Camerino, Dept Chem Sci, I-62032 Camerino, ItalyUniv Lille Nord France, Dept Biopharm Galen & Hosp Pharm, IFR114, EA 4481, F-59000 Lille, France
Di Martino, Piera
;
Barthelemy, Christine
论文数: 0引用数: 0
h-index: 0
机构:
Univ Lille Nord France, Dept Biopharm Galen & Hosp Pharm, IFR114, EA 4481, F-59000 Lille, FranceUniv Lille Nord France, Dept Biopharm Galen & Hosp Pharm, IFR114, EA 4481, F-59000 Lille, France
Barthelemy, Christine
;
Odou, Pascal
论文数: 0引用数: 0
h-index: 0
机构:
Univ Lille Nord France, Dept Biopharm Galen & Hosp Pharm, IFR114, EA 4481, F-59000 Lille, France
CHU Lille, Reg Univ Hosp Lille, Dept Pharm, F-59000 Lille, FranceUniv Lille Nord France, Dept Biopharm Galen & Hosp Pharm, IFR114, EA 4481, F-59000 Lille, France
机构:
Hoshi Univ, Fac Pharmaceut Sci, Dept Analyt Chem, Shinagawa Ku, 2-4-41 Ebara, Tokyo 1428501, JapanHoshi Univ, Fac Pharmaceut Sci, Dept Analyt Chem, Shinagawa Ku, 2-4-41 Ebara, Tokyo 1428501, Japan
Inoue, K
;
Kawaguchi, M
论文数: 0引用数: 0
h-index: 0
机构:
Hoshi Univ, Fac Pharmaceut Sci, Dept Analyt Chem, Shinagawa Ku, 2-4-41 Ebara, Tokyo 1428501, JapanHoshi Univ, Fac Pharmaceut Sci, Dept Analyt Chem, Shinagawa Ku, 2-4-41 Ebara, Tokyo 1428501, Japan
Kawaguchi, M
;
Okada, F
论文数: 0引用数: 0
h-index: 0
机构:
Hoshi Univ, Fac Pharmaceut Sci, Dept Analyt Chem, Shinagawa Ku, 2-4-41 Ebara, Tokyo 1428501, JapanHoshi Univ, Fac Pharmaceut Sci, Dept Analyt Chem, Shinagawa Ku, 2-4-41 Ebara, Tokyo 1428501, Japan
Okada, F
;
Yoshimura, Y
论文数: 0引用数: 0
h-index: 0
机构:
Hoshi Univ, Fac Pharmaceut Sci, Dept Analyt Chem, Shinagawa Ku, 2-4-41 Ebara, Tokyo 1428501, JapanHoshi Univ, Fac Pharmaceut Sci, Dept Analyt Chem, Shinagawa Ku, 2-4-41 Ebara, Tokyo 1428501, Japan
Yoshimura, Y
;
Nakazawa, H
论文数: 0引用数: 0
h-index: 0
机构:
Hoshi Univ, Fac Pharmaceut Sci, Dept Analyt Chem, Shinagawa Ku, 2-4-41 Ebara, Tokyo 1428501, JapanHoshi Univ, Fac Pharmaceut Sci, Dept Analyt Chem, Shinagawa Ku, 2-4-41 Ebara, Tokyo 1428501, Japan