A case of voltage-gated potassium channel antibody-related limbic encephalitis

被引：21
作者：
Harrower, T
Foltynie, T
Kartsounis, L
De Silva, RN
Hodges, JR
机构：
[1] Univ Cambridge, Addenbrookes Hosp, Dept Neurosci, Cambridge CB2 2QQ, England
[2] Oldchurch Hosp, Romford, Essex, England
来源：
NATURE CLINICAL PRACTICE NEUROLOGY | 2006年 / 2卷 / 06期
基金：
英国医学研究理事会;
关键词：
hyponatremia; immunomodulatory therapy; limbic encephalitis; voltage-gated potassium channel antibodies;
D O I：
10.1038/ncpneuro0194
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Background A 56-year-old man presented to hospital with a 6-month history of recurrent episodes of altered behavior and 'odd' episodes. He had become apathetic and uninterested in his family. He had no relevant past medical or family history. General and physical neurological examinations were unremarkable, as was bedside cognitive testing. Investigations Brain MRI scan, 24-h electroencephalogram, serum and cerebrospinal fluid testing for voltage-gated potassium channel antibodies, blood screening for tumors, CT scans of the chest, abdomen and pelvis, whole-body PET scan, neuropsychological examination, brain F-18-fluorodeoxyglucose-PET scan. Diagnosis Voltage-gated potassium channel antibody-related limbic encephalitis. Management Antiepileptic drugs, immunomodulatory therapy, oral steroids, plasma exchange.
引用
收藏
页码：339 / 343
页数：5
相关论文
共 17 条
[1]   Treatment-responsive limbic encephalitis identified by neuropil antibodies: MRI and PET correlates [J].
Ances, BM ;
Vitaliani, R ;
Taylor, RA ;
Liebeskind, DS ;
Voloschin, A ;
Houghton, DJ ;
Galetta, SL ;
Dichter, M ;
Alavi, A ;
Rosenfeld, MR ;
Dalmau, J .
BRAIN, 2005, 128 :1764-1777
[2]   Autoimmune channelopathies [J].
Buckley, C ;
Vincent, A .
NATURE CLINICAL PRACTICE NEUROLOGY, 2005, 1 (01) :22-33
[3]   Potassium channel antibodies in two patients with reversible limbic encephalitis [J].
Buckley, C ;
Oger, J ;
Clover, L ;
Tüzün, E ;
Carpenter, K ;
Jackson, M ;
Vincent, A .
ANNALS OF NEUROLOGY, 2001, 50 (01) :73-78
[4]   FDG-PET and MRI in potassium channel antibody-associated non-paraneoplastic limbic encephalitis: correlation with clinical course and neuropsychology [J].
Fauser, S ;
Talazko, J ;
Wagner, K ;
Ziyeh, S ;
Jarius, S ;
Vincent, A ;
Schulze-Bonhage, A .
ACTA NEUROLOGICA SCANDINAVICA, 2005, 111 (05) :338-343
[5]   Paraneoplastic limbic encephalitis: neurological symptoms, immunological findings and tumour association in 50 patients [J].
Gultekin, SH ;
Rosenfeld, MR ;
Voltz, R ;
Eichen, J ;
Posner, JB ;
Dalmau, J .
BRAIN, 2000, 123 :1481-1494
[6]   Rapid eye movement sleep behavior disorder and potassium channel antibody-associated limbic encephalitis [J].
Iranzo, A ;
Graus, F ;
Clover, L ;
Morera, J ;
Bruna, J ;
Vilar, C ;
Martínez-Rodriguez, JE ;
Vincent, A ;
Santamaría, J .
ANNALS OF NEUROLOGY, 2006, 59 (01) :178-182
[7]   Clinical, magnetic resonance imaging, and electroencephalographic findings in paraneoplastic limbic encephalitis [J].
Lawn, ND ;
Westmoreland, BF ;
Kiely, MJ ;
Lennon, VA ;
Vernino, S .
MAYO CLINIC PROCEEDINGS, 2003, 78 (11) :1363-1368
[8]   THE CASE FOR A DESCRIPTIVE GENERIC NOMENCLATURE - CLARIFICATION OF IMMUNOSTAINING CRITERIA FOR PCA-1, ANNA-1, AND ANNA-2 AUTOANTIBODIES [J].
LENNON, VA .
NEUROLOGY, 1994, 44 (12) :2412-2415
[9]   LIMBIC ENCEPHALITIS ASSOCIATED WITH MALIGNANT THYMOMA [J].
MCARDLE, JP ;
MILLINGEN, KS .
PATHOLOGY, 1988, 20 (03) :292-295
[10]   Autoimmune disorders of neuronal potassium channels [J].
Newsom-Davis, J ;
Buckley, C ;
Clover, L ;
Hart, I ;
Maddison, P ;
Tüzüm, E ;
Vincent, A .
MYASTHENIA GRAVIS AND RELATED DISORDERS: BIOMCHEMICAL BASIS FOR DISEASE OF THE NEUROMUSCULAR JUNCTION, 2003, 998 :202-210
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