Transient receptor potential channel A1 involved in calcitonin gene-related peptide release in neurons☆

被引：7

作者：

Ushio, Nobumasa ^{[1
]}

Dai, Yi ^{[1
,2
,3
]}

Wang, Shenglan ^{[1
,2
,3
]}

Fukuoka, Tetsuo ^{[1
]}

Noguchi, Koichi ^{[1
]}

机构：

[1] Hyogo Coll Med, Dept Anat & Neurosci, Nishinomiya, Hyogo 6638501, Japan

[2] Hyogo Univ Hlth Sci, Sch Pharm, Dept Pharm, Kobe, Hyogo 6508530, Japan

[3] Hyogo Coll Med, Chinese Med Confucius Inst, Tradit Med Res Ctr, Kobe, Hyogo 6508530, Japan

来源：

NEURAL REGENERATION RESEARCH | 2013年 / 8卷 / 32期

关键词：

neural regeneration; transient receptor potential channel A1; calcitonin gene-related peptide; dorsal root ganglion neurons; pain; hyperalgesia; noxious stimuli; sensory neuron; grants-supported paper; neuroregeneration; ROOT GANGLION NEURONS; INDUCED CGRP-RELEASE; NEUROGENIC PLASMA EXTRAVASATION; PRIMARY AFFERENT NEURONS; SUBSTANCE-P; NOCICEPTIVE NEURONS; SENSORY NEURONS; MESSENGER-RNAS; SPINAL-CORD; TRPA1;

D O I：

10.3969/j.issn.1673-5374.2013.32.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Transient receptor potential channel A1 is one of the important transducers of noxious stimuli in the primary afferents, which may contribute to generation of neurogenic inflammation and hyperA1gesia. The present study was designed to investigate if activation of transient receptor potential channel A1 may induce calcitonin gene-related peptide release from the primary afferent neurons. We found that application of Allyl isothiocyanate, a transient receptor potential channel A1 activator, caused calcitonin gene-related peptide release from the cultured rat dorsA1 root ganglion neurons. Knock-down of transient receptor potential channel A1 with an antisense oligodeoxynucleotide prevented calcitonin gene-related peptide release by Ally isothiocyanate application in cultured dorsA1 root ganglion neurons. Thus, we concluded that transient receptor potential channel A1 activation caused calcitonin gene-related peptide release in sensory neurons.

引用

页码：3013 / 3019

页数：7

共 41 条

[1] Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin [J].

Bandell, M ;

Story, GM ;

Hwang, SW ;

Viswanath, V ;

Eid, SR ;

Petrus, MJ ;

Earley, TJ ;

Patapoutian, A .

NEURON, 2004, 41 (06) :849-857

[2] TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents [J].

Bautista, DM ;

Jordt, SE ;

Nikai, T ;

Tsuruda, PR ;

Read, AJ ;

Poblete, J ;

Yamoah, EN ;

Basbaum, AI ;

Julius, D .

CELL, 2006, 124 (06) :1269-1282

[3] The role of calcitonin gene-related peptide on the increase in transient receptor potential vanilloid-1 levels in trigeminal ganglion and trigeminal nucleus caudalis activation of rat [J].

Chatchaisak, Duangthip ;

Srikiatkhachorn, Anan ;

Maneesri-le Grand, Supang ;

Govitrapong, Piyarat ;

Chetsawang, Banthit .

JOURNAL OF CHEMICAL NEUROANATOMY, 2013, 47 :50-56

[4] Cutaneous nociception evoked by 15-delta PGJ2 via activation of ion channel TRPAI [J].

Cruz-Orengo, Lillian ;

Dhaka, Ajay ;

Heuermann, Robert J. ;

Young, Timothy J. ;

Montana, Michael C. ;

Cavanaugh, Eric J. ;

Kim, Donghee ;

Story, Gina M. .

MOLECULAR PAIN, 2008, 4

[5]

Dai Y, 2002, J NEUROSCI, V22, P7737

[6] Sensitization of TRPA1 by PAR2 contributes to the sensation of inflammatory pain [J].

Dai, Yi ;

Wang, Shenglan ;

Tominaga, Makoto ;

Yamamoto, Satoshi ;

Fukuoka, Tetsuo ;

Higashi, Tomohiro ;

Kobayashi, Kimiko ;

Obata, Koichi ;

Yamanaka, Hiroki ;

Noguchi, Koichi .

JOURNAL OF CLINICAL INVESTIGATION, 2007, 117 (07) :1979-1987

[7] The proximodistal aggravation of colitis depends on substance P released from TRPV1-expressing sensory neurons [J].

Engel, Matthias A. ;

Khalil, Mohammad ;

Mueller-Tribbensee, Sonja M. ;

Becker, Christoph ;

Neuhuber, Winfried L. ;

Neurath, Markus F. ;

Reeh, Peter W. .

JOURNAL OF GASTROENTEROLOGY, 2012, 47 (03) :256-265

[8] Intracellular alkalization causes pain sensation through activation of TRPA1 in mice [J].

Fujita, Fumitaka ;

Uchida, Kunitoshi ;

Moriyama, Tomoko ;

Shima, Asako ;

Shibasaki, Koji ;

Inada, Hitoshi ;

Sokabe, Takaaki ;

Tominaga, Makoto .

JOURNAL OF CLINICAL INVESTIGATION, 2008, 118 (12) :4049-4057

[9]

Gannse R, 1980, BRIT J PHARMACOL, V68, P207

[10] Capsaicin-evoked release of immunoreactive calcitonin gene-related peptide from the spinal cord is mediated by nitric oxide but not by cyclic GMP [J].

Garry, MG ;

Walton, LP ;

Davis, MA .

BRAIN RESEARCH, 2000, 861 (02) :208-219

← 1 2 3 4 5 →