β-Carboline harmine reverses the effects induced by stress on behaviour and citrate synthase activity in the rat prefrontal cortex

被引：13

作者：

Abelaira, Helena Mendes ^{[1
]}

Reus, Gislaine Zilli ^{[1
]}

Scaini, Giselli ^{[2
]}

Streck, Emilio Luiz ^{[2
]}

Crippa, Jose Alexandre ^{[3
]}

Quevedo, Joao ^{[1
]}

机构：

[1] Univ Extremo Sul Catarinense, Unidade Acad Ciencias Saude, Program Posgrad Ciencias Saude, Lab Neurociencias,INCT TM,NENASC, Criciuma, SC, Brazil

[2] Univ Extremo Sul Catarinense, Unidade Acad Ciencias Saude, Program Posgrad Ciencias Saude, Lab Bioenerget,INCT TM, Criciuma, SC, Brazil

[3] Univ Sao Paulo, Fac Med Ribeirao Preto, Inst Ciencia & Tecnol Translac Med, Dept Neurociencias & Ciencias Comportamento, BR-14049 Ribeirao Preto, SP, Brazil

来源：

ACTA NEUROPSYCHIATRICA | 2013年 / 25卷 / 06期

关键词：

chronic mild stress; citrate synthase; depression; harmine; HIPPOCAMPAL; CORTICOSTERONE; ANTAGONIST; HARMANE; MEMORY; YOUNG; TASK;

D O I：

10.1017/neu.2013.20

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Objectives The present study was aimed at evaluating the effects of the administration of -carboline harmine on behaviour and citrate synthase activity in the brain of rats exposed to chronic mild stress (CMS) procedure. Methods To this aim, after 40 days of exposure to CMS procedure, rats were treated with harmine (15 mg/kg/day) for 7 days, then memory, anhedonia and citrate synthase activity were assessed. Result Our findings demonstrated that stressed rats treated with saline increased the sucrose intake, and the stressed rats treated with harmine reversed this effect. Neither stress nor harmine treatment altered memory performance in rats. In addition, chronic stressful situations induced increase in citrate synthase activity in the prefrontal cortex, but not in the hippocampus and striatum. Treatment with harmine reversed the increase in citrate synthase activity in the prefrontal cortex. Conclusion These findings support the hypothesis that harmine could be involved in controlling the energy metabolism.

引用

页码：328 / 333

页数：6

共 33 条

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