Total Synthesis of Bacilosarcins A and B

被引：38

作者：

Enomoto, Masaru ^{[1
]}

Kuwahara, Shigefumi ^{[1
]}

机构：

[1] Tohoku Univ, Lab Appl Bioorgan Chem, Grad Sch Agr Sci, Aoba Ku, Sendai, Miyagi 9818555, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 06期

关键词：

alkaloids; epoxidation; heterocycles; natural products; total synthesis; MICROBIAL AGENT AI-77-B; BACILLUS-PUMILUS AI-77; AMINO-ACID MOIETY; STEREOSELECTIVE-SYNTHESIS; GASTROPROTECTIVE SUBSTANCE; ALPHA; BETA-UNSATURATED ALDEHYDES; DIHYDROISOCOUMARIN MOIETY; AMADORI REARRANGEMENT; ASYMMETRIC-SYNTHESIS; ORGANIC-SYNTHESIS;

D O I：

10.1002/anie.200804571

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) I want to ride my bicycle: The thermodynamic stability of nitrogen-containing heterocyclic ring systems is exploited in the first enantioselective total synthesis of bacilosarcins A and B, which has been achieved in simple two-step sequences from amicoumacin C. Bacilosarcin A incorporates a totally unprecedented heterobicyclic ring system and exhibits a remarkably potent herbicidal activity. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：1144 / 1148

页数：5

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