Risk of Advanced Age-Related Macular Degeneration after Cataract Surgery in the Age-Related Eye Disease Study AREDS Report 25

被引：111

作者：

Chew, Emily Y. ^{[1
]}

Sperduto, Robert. D. ^{[3
]}

Milton, Roy C. ^{[3
]}

Clemons, Traci E. ^{[3
]}

Gensler, Gary R. ^{[3
]}

Bressler, Susan B. ^{[2
]}

Klein, Ronald ^{[4
]}

Klein, Barbara E. K. ^{[4
]}

Ferris, Frederick L., III ^{[1
]}

机构：

[1] NEI, Bethesda, MD 20892 USA

[2] Johns Hopkins Wilmer Eye Inst, Baltimore, MD USA

[3] EMMES Corp, Rockville, MD USA

[4] Univ Wisconsin, Sch Med & Publ Hlth, Madison, WI USA

来源：

OPHTHALMOLOGY | 2009年 / 116卷 / 02期

基金：

美国国家卫生研究院;

关键词：

BEAVER DAM; MACULOPATHY; ASSOCIATION; EXTRACTION;

D O I：

10.1016/j.ophtha.2008.09.019

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Purpose: To assess the risk of advanced age-related macular degeneration (AMD) developing after cataract surgery. Design: Cohort study. Participants: Four thousand five hundred seventy-seven participants (8050 eyes) from a multicenter, controlled, randomized clinical trial, the Age-Related Eye Disease Study (AREDS). Methods: Development of advanced AMD, either neovascular (NV) AMD or geographic atrophy (GA), was evaluated with annual fundus photographs, and history of cataract surgery was assessed every 6 months. Cox proportional hazard models with time-dependent covariates were conducted for NV AMD and GA separately. Main Outcome Measures: Neovascular AMD, GA, and central GA (CGA; involving the center of the macula). Results: The Cox proportional hazards model of right eyes showed nonsignificant hazard ratios of 1.20 (95% confidence interval [CI], 0.82-1.75) for NV AMD, 0.80 (95% CI, 0.61-1.06) for GA, and 0.87 (95% CI, 0.64-1.18) for CGA. Similar results were obtained for left eyes: 1.07 (95% CI, 0.72-1.58) for NV AMD, 0.94 (95% CI, 0.71-1.25) for GA, and 0.86 (95% CI, 0.63-1.19) for CGA. For participants with advanced AMD in 1 eye (AREDS category 4), the hazard ratios for fellow eyes were 1.08 (95% CI, 0.65-1.72) for NV AMD and 0.98 (95% CI, 0.64-1.49) for CGA. Conclusions. The AREDS results show-ad no clear effect of cataract surgery on the risk of progression to advanced AMD. Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article. Ophthalmology 2009;116:297-303 (C) 2009 by the American Academy of Ophthalmology.

引用

页码：297 / 303

页数：7

共 22 条

[1]

*AG REL EYE DIS ST, 2001, AM J OPHTHALMOL, V12, P668

[2]

Anand R, 2000, OPHTHALMOLOGY, V107, P2224

[3] Cataract surgery in patients with age-related macular degeneration - One-year outcomes [J].