Life Expectancy and Death by Diseases of the Circulatory System in Patients with Bipolar Disorder or Schizophrenia in the Nordic Countries

被引:239
作者
Laursen, Thomas Munk [1 ,3 ]
Wahlbeck, Kristian [3 ,9 ]
Hallgren, Jonas [4 ]
Westman, Jeanette [5 ]
Osby, Urban [5 ,6 ,7 ,8 ]
Alinaghizadeh, Hassan [5 ]
Gissler, Mika [3 ,9 ]
Nordentoft, Merete [2 ,3 ]
机构
[1] Aarhus Univ, Natl Ctr Register Based Res, iPSYCH, Aarhus, Denmark
[2] Univ Copenhagen, Fac Hlth Sci, Psychiat Ctr Copenhagen, Copenhagen, Denmark
[3] Nordic Sch Publ Hlth, Nordic Res Acad Mental Hlth, Gothenburg, Sweden
[4] Karolinska Inst, Dept Med Epidemiol & Biostat MEB, Stockholm, Sweden
[5] Karolinska Inst, Dept Neurobiol Care Sci & Soc, Ctr Family Med, Stockholm, Sweden
[6] Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden
[7] Karolinska Inst, Ctr Mol Med, Stockholm, Sweden
[8] Tiohundra AB, Dept Psychiat, Norrtalje, Sweden
[9] THL Natl Inst Hlth & Welf, Helsinki, Finland
关键词
CAUSE-SPECIFIC MORTALITY; EXCESS MORTALITY; PREMATURE MORTALITY; MENTAL-DISORDER; ILLNESS; SWEDEN; RISK; CERTIFICATES; STATISTICS; REGISTER;
D O I
10.1371/journal.pone.0067133
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Objective: Excess mortality from diseases and medical conditions (natural death) in persons with psychiatric disorders has been extensively reported. Even in the Nordic countries with well-developed welfare systems, register based studies find evidence of an excess mortality. In recent years, cardiac mortality and death by diseases of the circulatory system has seen a decline in all the Nordic countries, but a recent paper indicates that women and men in Denmark, Finland, and Sweden, who had been hospitalised for a psychotic disorder, had a two to three-fold increased risk of dying from a cardiovascular disease. The aim of this study was to compare the mortality by diseases of the circulatory system among patients with bipolar disorder or schizophrenia in the three Nordic countries Denmark, Sweden, and Finland. Furthermore, the aim was to examine and compare life expectancy among these patients. Cause specific Standardized Mortality Rates (SMRs) were calculated for each specific subgroup of mortality. Life expectancy was calculated using Wiesler's method. Results: The SMR for bipolar disorder for diseases of the circulatory system was approximately 2 in all countries and both sexes. SMR was slightly higher for people with schizophrenia for both genders and in all countries, except for men in Denmark. Overall life expectancy was much lower among persons with bipolar disorder or schizophrenia, with life expectancy being from 11 to 20 years shorter. Conclusion: Our data show that persons in the Nordic countries with schizophrenia or bipolar disorder have a substantially reduced life expectancy. An evaluation of the reasons for these increased mortality rates should be prioritized when planning healthcare in the coming years.
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页数:7
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