Regulatory elements in the viral genome

被引：87
作者：
Bernard, Hans-Ulrich [1 ,2 ]
机构：
[1] Univ Calif Irvine, Dept Mol Biol & Biochem, Irvine, CA 92617 USA
[2] Univ Calif Irvine, Program Publ Hlth, Irvine, CA 92617 USA
来源：
VIROLOGY | 2013年 / 445卷 / 1-2期
关键词：
Transcription of papillomaviruses; Regulation of gene expression of papillomaviruses; Cis-responsive elements; Transcription factors; HUMAN-PAPILLOMAVIRUS TYPE-16; LONG CONTROL REGION; NUCLEAR FACTOR-I; CCAAT DISPLACEMENT PROTEIN; HOST TRANSCRIPTION FACTORS; MATRIX ATTACHMENT REGIONS; E6; PROMOTER; C/EBP-BETA; BINDING-SITES; E2; PROTEIN;
D O I：
10.1016/j.virol.2013.04.035
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The small DNA genomes of papillomaviruses contain a surprisingly large number of regulatory or cis-responsive elements, which regulate replication and transcription of the virus, and control details like specificity for certain epithelial cells, specificity for layers in squamous epithelia, feedback mechanisms and coupling between host cell physiology and virus biology. Most of these elements occur in the long control region, while others are located elsewhere in the genome. Many papillomaviruses show a similar composition of cis-responsive elements, although these are scattered and do not occur as long segments of sequence similarity. This review summarizes our knowledge of the regulatory elements in several well-studied Alphapapillomavirus types, and indicates some similarities to other papillomavirus genera, whose properties are yet poorly understood. (C) 2013 Elsevier Inc. All rights reserved.
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页码：197 / 204
页数：8
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