Monosodium glutamate-induced oxidative kidney damage and possible mechanisms: a mini-review

被引：74

作者：

Sharma, Amod ^{[1
,2
]}

机构：

[1] Mahidol Univ, Siriraj Hosp, Dept Physiol, Bangkok 10700, Thailand

[2] Khon Kaen Univ, Fac Med, Dept Biochem, Khon Kaen 40002, Thailand

来源：

JOURNAL OF BIOMEDICAL SCIENCE | 2015年 / 22卷

关键词：

Monosodium glutamate; Kidney; Oxidative stress; Glutamate receptors; alpha-Ketoglutarate dehydrogenase; ALPHA-KETOGLUTARATE DEHYDROGENASE; ANTIPORTER SYSTEM X(C)(-); OXYGEN SPECIES PRODUCTION; REACTIVE OXYGEN; LIPID-PEROXIDATION; INDUCED CYTOTOXICITY; HIPPOCAMPAL-NEURONS; SIGNAL-TRANSDUCTION; PROTEIN-KINASE; VITAMIN-C;

D O I：

10.1186/s12929-015-0192-5

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Animal studies suggest that chronic monosodium glutamate (MSG) intake induces kidney damage by oxidative stress. However, the underlying mechanisms are still unclear, despite the growing evidence and consensus that alpha-ketoglutarate dehydrogenase, glutamate receptors and cystine-glutamate antiporter play an important role in up-regulation of oxidative stress in MSG-induced renal toxicity. This review summaries evidence from studies into MSG-induced renal oxidative damage, possible mechanisms and their importance from a toxicological viewpoint.

引用

页数：6