Location- and sex-specific differences in weight and motor coordination in two commonly used mouse strains

被引：27

作者：

Kovacs, Attila D. ^{[1
]}

Pearce, David A. ^{[1
,2
]}

机构：

[1] Sanford Res USD, Sanford Childrens Hlth Res Ctr, Sioux Falls, SD 57104 USA

[2] Univ S Dakota, Sanford Sch Med, Dept Pediat, Sioux Falls, SD 57104 USA

来源：

SCIENTIFIC REPORTS | 2013年 / 3卷

基金：

美国国家卫生研究院;

关键词：

HUNTINGTONS-DISEASE; ENVIRONMENT; MICE; DEFICITS; C57BL/6J; KNOCKOUT; BEHAVIOR; GENETICS; ETHANOL; CYCLE;

D O I：

10.1038/srep02116

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Several studies have shown that environmental factors can affect the outcome of behavioral experiments, shedding doubts on the inter-laboratory reproducibility of behavioral test results. When our laboratory moved from the University of Rochester, Rochester, NY, to Sanford Research in Sioux Falls, SD, our mouse colony was also transferred and the new environment caused strain-dependent changes in the weight, motor coordination and motor learning capability of mice. Here we report the observed changes for two wild type mouse strains commonly used in transgenic studies, C57BL/6J and 129S6/SvEv, and show that the type of rodent diet is partially responsible for the geographical location-specific differences. We also found sex-specific differences in weight and motor coordination in both mouse strains. Our results show that environmental factors specific to a geographical location can change the body weight, motor coordination and motor learning capability of wild type mice commonly used as controls in transgenic studies.

引用

页数：7