The paradox of overnutrition in aging and cognition

被引：17

作者：

Fielding, Roger A. ^{[1
]}

Gunstad, John ^{[2
]}

Gustafson, Deborah R. ^{[3
,4
]}

Heymsfield, Steven B. ^{[5
]}

Kral, John G. ^{[6
]}

Launer, Lenore J. ^{[7
]}

Penninger, Josef ^{[8
]}

Phillips, David I. W. ^{[9
]}

Scarmeas, Nikolaos ^{[10
,11
]}

机构：

[1] Tufts Univ, Nutr Exercise Physiol & Sarcopenia Lab, Boston, MA USA

[2] Kent State Univ, Dept Psychol, Kent, OH 44242 USA

[3] Suny Downstate Med Ctr, Dept Neurol, Brooklyn, NY 11203 USA

[4] Univ Gothenburg, Neuropsychiat Epidemiol Res Unit, Gothenburg, Sweden

[5] Louisiana State Univ, Pennington Biomed Res Ctr, Baton Rouge, LA USA

[6] Suny Downstate Med Ctr, Dept Surg & Med, Brooklyn, NY 11203 USA

[7] Natl Inst Aging, Lab Epidemiol Demog & Biometry, Intramural Res Program, Bethesda, MD USA

[8] Austrian Acad Sci, Inst Mol Biotechnol, A-1010 Vienna, Austria

[9] Univ Southampton, Lifecourse Epidemiol Unit, Southampton, Hants, England

[10] Columbia Univ, Coll Phys & Surg, Dept Neurol, New York, NY USA

[11] Univ Athens, Athens, Greece

来源：

ANNALS MEETING REPORTS | 2013年 / 1287卷

关键词：

overnutrition; obesity; cognitive decline; Alzheimer's disease; sarcopenia; ALZHEIMERS-DISEASE;

D O I：

10.1111/nyas.12138

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Populations of many countries are becoming increasingly overweight and obese, driven largely by excessive calorie intake and reduced physical activity; greater body mass is accompanied by epidemic levels of comorbid metabolic diseases. At the same time, individuals are living longer. The combination of aging and the increased prevalence of metabolic disease is associated with increases in aging-related comorbid diseases such as Alzheimer's disease, cerebrovascular dementia, and sarcopenia. Here, correlative and causal links between diseases of overnutrition and diseases of aging and cognition are explored.

引用

页码：31 / 43

页数：13

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