Serum sterols in patients with primary biliary cirrhosis and acute liver failure before and after liver transplantation

Background/Aims:Liver diseases modify sterol metabolism. Liver transplantation (LTX) provides a model to evaluate the impact of disease-affected liver on sterol metabolism. Methods: We studied serum sterol profiles and their relationships to other biochemical markers in consecutive cholestatic patients with acute liver failure (ALF, n = 39) and end-stage primary biliary cirrhosis (PBC, n = 67) before and 27d after LTX. Accordingly, we determined serum levels of sterols, bilirubin and prealbumin. Results: Due to weak cholesterol synthesis of ALF-patients before LTX, their serum levels of cholesterol, lathosterol/cholesterol, cholestanol/cholesterol and lathosterol/campesterol were 18%-41%, lower (P < 0.05 for each) than in PBC, but ratios of phytosterols to cholesterol were equal. In general, non-cholesterol sterol ratios reflected bilirubin and prealbumin concentrations. Interrelation of surrogate sterols showed that homeostasis of cholesterol metabolism prevailed in lowest cholestanol tertile of ALF-patients consistently, but not in PBC. After LTX, cholesterol levels and lathosterol ratios increased in both groups and phytosterol ratios decreased (P < 0.01). Cholestanol decreased profoundly in PBC, but remained 26% higher than in ALF (P < 0.05). Conclusions: Homeostasis of cholesterol metabolism was maintained only in ALF. Metabolism of phytosterols was equal in study groups. PBC and ALF-patients have differential patterns in their serum sterols and cholesterol metabolism. (C) 2008 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.