In Vivo Electrochemical Detection of Nitroglycerin-Derived Nitric Oxide in Tumor-Bearing Mice

被引：11

作者：

Griveau, Sophie ^{[1
]}

Seguin, Johanne ^{[1
]}

Scherman, Daniel ^{[1
]}

Chabot, Guy G. ^{[1
]}

Bedioui, Fethi ^{[1
]}

机构：

[1] Univ Paris 05, ENSCP, Unite Pharmacol Chim & Genet, CNRS 8151,Ecole Natl Super Chim Paris,INSERM 640, F-75231 Paris 05, France

来源：

ELECTROANALYSIS | 2009年 / 21卷 / 3-5期

关键词：

Tumor; In vivo detection; Nitric oxide; Nitroglycerin; NO-sensor; Electrochemical detection;

D O I：

10.1002/elan.200804300

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The ability of an inserted electrode to detect in vivo NO in tumor was achieved by using a chemically modified Pt/Ir electrode as NO-sensor and nitroglycerin NTG as NO donor. Enzymatically induced release of NO from NTG was tracked in the tumor, upon intra peritoneal injection of NTG. This approach allowed in vivo monitoring of the bioavailability of NO and could be applied to the in vivo study of candidate anticancer drugs acting oil the NO pathways.

引用

页码：631 / 634

页数：4

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