Mechanical clearance of red blood cells by the human spleen: Potential therapeutic applications of a biomimetic RBC filtration method

被引：31

作者：

Duez, J. ^{[1
,2
,3
,4
]}

Holleran, J. P. ^{[4
]}

Ndour, P. A. ^{[1
,2
]}

Pionneau, C. ^{[5
]}

Diakite, S. ^{[1
,2
]}

Roussel, C. ^{[2
,6
,7
]}

Dussiot, M. ^{[2
,6
,7
]}

Amireault, P. ^{[2
,6
,7
]}

Avery, V. M. ^{[4
]}

Buffet, P. A. ^{[1
,2
]}

机构：

[1] Hop La Pitie Salpetriere, Equipe 4, CIMI Paris U1135, F-75013 Paris, France

[2] Lab Excellence GR Ex, F-75015 Paris, France

[3] HRA Pharma Labs, F-75003 Paris, France

[4] Griffith Univ, Eskitis Inst Drug Discovery, Nathan, Qld 4111, Australia

[5] Hop La Pitie Salpetriere, CIMI Paris Plateforme Postgenom Pitie Salpetriere, F-75013 Paris, France

[6] Paris Descartes Sorbonne Paris Cite Univ, Imagine Inst, CNRS ERL 8254, INSERM U1163, F-75015 Paris, France

[7] INTS, F-75015 Paris, France

来源：

TRANSFUSION CLINIQUE ET BIOLOGIQUE | 2015年 / 22卷 / 03期

关键词：

Erythrocyte; Deformability; Spleen; Filtration; Microspheres; Malaria; Transfusion; Applications; HIGH-THROUGHPUT ASSAY; ERYTHROCYTE DEFORMABILITY; SPLENIC FUNCTION; MALARIA; STORAGE; IDENTIFICATION; TRANSFUSION; IMMUNE; MODEL; TRANSMISSION;

D O I：

10.1016/j.tracli.2015.05.004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

During their lifespan, circulating RBC are frequently checked for their deformability. This mechanical quality control operates essentially in the human spleen. RBC unable to squeeze though narrow splenic slits are retained and cleared from the blood circulation. Under physiological conditions this prevents microvessels from being clogged by senescent, rigid RBC. Retention of poorly deformable RBC is an important determinant of pathogenesis in malaria and may also impact the clinical benefit of transfusion. Modulating the splenic retention of RBC has already been proposed to support therapeutic approaches in these research fields. To this aim, the development of microplates for high throughput filtration of RBC through microsphere layers (microplate-based microsphiltration) has been undertaken. This review focuses on potential therapeutic applications provided by this technology in malaria chemotherapy and transfusion. (C) 2015 Elsevier Masson SAS. All rights reserved.

引用

页码：151 / 157

页数：7

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