DIANA-miRPath v3.0: deciphering microRNA function with experimental support

被引：1375

作者：

Vlachos, Ioannis S. ^{[1
,2
]}

Zagganas, Konstantinos ^{[3
,4
]}

Paraskevopoulou, Maria D. ^{[1
]}

Georgakilas, Georgios ^{[1
]}

Karagkouni, Dimitra ^{[1
]}

Vergoulis, Thanasis ^{[3
]}

Dalamagas, Theodore ^{[3
]}

Hatzigeorgiou, Artemis G. ^{[1
,3
]}

机构：

[1] Univ Thessaly, Dept Elect & Comp Engn, DIANA Lab, Volos 38221, Greece

[2] Univ Athens, Med Sch Athens, Lab Expt Surg & Surg Res NS Christeas, Athens 11527, Greece

[3] Athena Res & Innovat Ctr, Athens 11524, Greece

[4] Univ Peloponnisos, Dept Informat & Telecommun, Tripoli 22100, Greece

来源：

NUCLEIC ACIDS RESEARCH | 2015年 / 43卷 / W1期

关键词：

GENE ONTOLOGY; LISTS; TOOL;

D O I：

10.1093/nar/gkv403

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The functional characterization of miRNAs is still an open challenge. Here, we present DIANA-miRPath v3.0 (http://www.microrna.gr/miRPathv3) an online software suite dedicated to the assessment of miRNA regulatory roles and the identification of controlled pathways. The new miRPath web server renders possible the functional annotation of one or more miRNAs using standard (hypergeometric distributions), unbiased empirical distributions and/or meta-analysis statistics. DIANA-miRPath v3.0 database and functionality have been significantly extended to support all analyses for KEGGmolecular pathways, as well as multiple slices of Gene Ontology (GO) in seven species (Homo sapiens, Mus musculus, Rattus norvegicus, Drosophila melanogaster, Caenorhabditis elegans, Gallus gallus and Danio rerio). Importantly, more than 600 000 experimentally supported miRNA targets from DIANA-TarBase v7.0 have been incorporated into the new schema. Users of DIANA-miRPath v3.0 can harness this wealth of information and substitute or combine the available in silico predicted targets from DIANA-microT-CDS and/or TargetScan v6.2 with high quality experimentally supported interactions. A unique feature of DIANA-miRPath v3.0 is its redesigned Reverse Search module, which enables users to identify and visualize miRNAs significantly controlling selected pathways or belonging to specific GO categories based on in silico or experimental data. DIANA-miRPath v3.0 is freely available to all users without any login requirement.

引用

页码：W460 / W466

页数：7

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