The Behavioral and Psychological Symptoms of Dementia in Down Syndrome (BPSD-DS) Scale: Comprehensive Assessment of Psychopathology in Down Syndrome

被引：37

作者：

Dekker, Alain D. ^{[1
,2
,3
]}

Sacco, Silvia ^{[4
]}

Carfi, Angelo ^{[5
]}

Benejam, Bessy ^{[6
]}

Vermeiren, Yannick ^{[1
,2
,3
]}

Beugelsdijk, Gonny ^{[7
]}

Schippers, Mieke ^{[7
]}

Hassefras, Lyanne ^{[7
]}

Eleveld, Jose ^{[8
]}

Grefelman, Sharina ^{[8
]}

Fopma, Roelie ^{[9
]}

Bomer-Veenboer, Monique ^{[10
]}

Boti, Mariangeles ^{[6
]}

Oosterling, G. Danielle E. ^{[11
]}

Scholten, Esther ^{[12
]}

Tollenaere, Marleen ^{[13
,14
]}

Checkley, Laura ^{[15
]}

Strydom, Andre ^{[15
]}

Van Goethem, Gert ^{[16
,17
]}

Onder, Graziano ^{[5
]}

Blesa, Rafael ^{[18
]}

zu Eulenburg, Christine ^{[19
]}

Coppus, Antonia M. W. ^{[20
,21
]}

Rebillat, Anne-Sophie ^{[4
]}

Fortea, Juan ^{[6
,18
]}

De Deyn, Peter P. ^{[1
,2
,3
,13
,14
]}

机构：

[1] Univ Groningen, Univ Med Ctr Groningen, Dept Neurol, Groningen, Netherlands

[2] Univ Groningen, Univ Med Ctr Groningen, Alzheimer Res Ctr, Groningen, Netherlands

[3] Univ Antwerp, Inst Born Bunge, Lab Neurochem & Behav, Antwerp, Belgium

[4] Inst Jerome Lejeune, Paris, France

[5] Univ Cattolica Sacro Cuore, Policlin Gemelli, Dept Geriatr, Rome, Italy

[6] Catalan Down Syndrome Fdn, Down Med Ctr, Barcelona, Spain

[7] Ipse Bruggen, Ctr Intellectual Disabil, Nieuwveen Zwammerdam, Netherlands

[8] Cosis, Ctr Intellectual Disabil, Groningen, Netherlands

[9] Talant, Ctr Intellectual Disabil, Heerenveen, Netherlands

[10] Pameijer, Ctr Intellectual Disabil, Rotterdam, Netherlands

[11] Aveleijn, Ctr Intellectual Disabil, Borne, Netherlands

[12] Elver, Ctr Intellectual Disabil, Nieuw Wehl, Netherlands

[13] Hosp Network Antwerp ZNA Middelheim & Hoge Beuken, Dept Neurol, Antwerp, Belgium

[14] Hosp Network Antwerp ZNA Middelheim & Hoge Beuken, Memory Clin, Antwerp, Belgium

[15] UCL, Div Psychiat, London, England

[16] NHet GielsBos, Ctr Intellectual Disabil, Gierle, Belgium

[17] Univ Hosp Antwerp, Dept Neurol, Antwerp, Belgium

[18] Univ Autonoma Barcelona, Biomed Res Inst Sant Pau, Hosp Santa Creu & Sant Pau, Dept Neurol, Barcelona, Spain

[19] Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands

[20] Ctr Intellectual Disabil, Dichterbij, Gennep, Netherlands

[21] Radboud Univ Nijmegen, Med Ctr, Dept Primary & Community Care, Nijmegen, Netherlands

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2018年 / 63卷 / 02期

关键词：

Alzheimer's disease; behavior; BPSD; dementia; Down syndrome; neuropsychiatric symptoms; trisomy; 21; MILD COGNITIVE IMPAIRMENT; ALZHEIMER-DISEASE-CONSORTIUM; NEUROPSYCHIATRIC INVENTORY; INTELLECTUAL DISABILITIES; MALADAPTIVE BEHAVIORS; PSYCHIATRIC-SYMPTOMS; DIAGNOSTIC-CRITERIA; NATURAL-HISTORY; ADULTS; INDIVIDUALS;

D O I：

10.3233/JAD-170920

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

People with Down syndrome (DS) are prone to develop Alzheimer's disease (AD). Behavioral and psychological symptoms of dementia (BPSD) are core features, but have not been comprehensively evaluated in DS. In a European multidisciplinary study, the novel Behavioral and Psychological Symptoms of Dementia in Down Syndrome (BPSD-DS) scale was developed to identify frequency and severity of behavioral changes taking account of life-long characteristic behavior. 83 behavioral items in 12 clinically defined sections were evaluated. The central aim was to identify items that change in relation to the dementia status, and thus may differentiate between diagnostic groups. Structured interviews were conducted with informants of persons with DS without dementia (DS, n = 149), with questionable dementia (DS+Q, n = 65), and with diagnosed dementia (DS+AD, n = 67). First exploratory data suggest promising interrater, test-retest, and internal consistency reliability measures. Concerning item relevance, group comparisons revealed pronounced increases in frequency and severity in items of anxiety, sleep disturbances, agitation & stereotypical behavior, aggression, apathy, depressive symptoms, and eating/drinking behavior. The proportion of individuals presenting an increase was highest in DS+AD, intermediate in DS+Q, and lowest in DS. Interestingly, among DS+Q individuals, a substantial proportion already presented increased anxiety, sleep disturbances, apathy, and depressive symptoms, suggesting that these changes occur early in the course of AD. Future efforts should optimize the scale based on current results and clinical experiences, and further study applicability, reliability, and validity. Future application of the scale in daily care may aid caregivers to understand changes, and contribute to timely interventions and adaptation of caregiving.

引用

页码：797 / 819

页数：23

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