Plasma-derived C1-INH for managing hereditary angioedema in pediatric patients: A systematic review

被引：15

作者：

Craig, Timothy J. ^{[1
]}

Schneider, Lynda C. ^{[1
,2
,3
]}

MacGinnitie, Andrew J. ^{[1
,2
,3
]}

机构：

[1] Penn State Univ, Dept Med & Pediat, Hershey, PA 17033 USA

[2] Boston Childrens Hosp, Div Immunol, Boston, MA USA

[3] Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA

来源：

PEDIATRIC ALLERGY AND IMMUNOLOGY | 2015年 / 26卷 / 06期

关键词：

plasma-derived C1-inhibitor; children; efficacy; hereditary angioedema; pediatric; safety; Berinert; Cinryze; C1 INHIBITOR DEFICIENCY; SHORT-TERM PROPHYLAXIS; CONCENTRATE; MANAGEMENT; ATTACKS; EDEMA; CHILDREN; THERAPY; UPDATE; COHORT;

D O I：

10.1111/pai.12425

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Presently, medications approved for children with Hereditary Angioedema (HAE) are extremely limited. This is especially the case for children under 12 years of age. For this reason we reviewed and summarized the data on treatment of children with HAE. Available data indicate that plasma derived C1-inhibitor is a safe, effective treatment option for HAE in pediatric patients, including those below 12 years of age. Other therapies are also appear safe for the under 12 year of age, but less data are available. Importantly, home-based treatment of HAE in this age group appears to be safe and effective and can improve quality of life. These findings support current HAE consensus guidelines which strongly recommend the use of plasma derived C1-inhibitor as a first-line treatment in children and encourage home and self-treatment.

引用

页码：537 / 544

页数：8

共 53 条

[1] Hereditary Angioedema: Children Should be Considered for Training in Self-Administration [J].

Abdel-Karim, Omar ;

Dizdarevic, Adis ;

Bygum, Anette .

PEDIATRIC DERMATOLOGY, 2014, 31 (06) :E132-E135

[2] Hereditary angio-oedema in children [J].

Abinun, M .

LANCET, 1999, 353 (9171) :2242-2242

[3]

Aerzteschaft AdD, 2000, DTSCH AERZTEBL, V97, pB864

[4] HEREDITARY AND ACQUIRED C1-INHIBITOR DEFICIENCY - BIOLOGICAL AND CLINICAL CHARACTERISTICS IN 235 PATIENTS [J].

AGOSTONI, A ;

CICARDI, M .

MEDICINE, 1992, 71 (04) :206-215

[5]

[Anonymous], 2011, BER HUM C1 EST INH H

[6]

[Anonymous], 2012, CINR HUM C1 EST INH

[7] Management of occlusion and thrombosis associated with long-term indwelling central venous catheters [J].

Baskin, Jacquelyn L. ;

Pui, Ching-Hon ;

Reiss, Ulrike ;

Wilimas, Judith A. ;

Metzger, Monika L. ;

Ribeiro, Raul C. ;

Howard, Scott C. .

LANCET, 2009, 374 (9684) :159-169

[8] Canadian hereditary angioedema guideline [J].

Betschel, Stephen ;

Badiou, Jacquie ;

Binkley, Karen ;

Hebert, Jacques ;

Kanani, Amin ;

Keith, Paul ;

Lacuesta, Gina ;

Yang, Bill ;

Aygoeren-Puersuen, Emel ;

Bernstein, Jonathan ;

Bork, Konrad ;

Caballero, Teresa ;

Cicardi, Marco ;

Craig, Timothy ;

Farkas, Henriette ;

Longhurst, Hilary ;

Zuraw, Bruce ;

Boysen, Henrik ;

Borici-Mazi, Rozita ;

Bowen, Tom ;

Dallas, Karen ;

Dean, John ;

Lang-Robertson, Kelly ;

Laramee, Benoit ;

Leith, Eric ;

Mace, Sean ;

McCusker, Christine ;

Moote, Bill ;

Poon, Man-Chiu ;

Ritchie, Bruce ;

Stark, Donald ;

Sussman, Gordon ;

Waserman, Susan .

ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY, 2014, 10

[9] Hereditary angioedema: New findings concerning symptoms, affected organs, and course [J].

Bork, K ;

Meng, G ;

Staubach, P ;

Hardt, J .

AMERICAN JOURNAL OF MEDICINE, 2006, 119 (03) :267-274

[10] Treatment with C1 inhibitor concentrate in abdominal pain attacks of patients with hereditary angioedema [J].

Bork, K ;

Meng, G ;

Staubach, P ;

Hardt, J .

TRANSFUSION, 2005, 45 (11) :1774-1784

← 1 2 3 4 5 6 →