Viral infections of the central nervous system in Spain: A prospective study

被引：111

作者：

de Ory, F. ^{[1
,2
]}

Avellon, A. ^{[1
]}

Echevarria, J. E. ^{[1
,2
]}

Sanchez-Seco, M. P. ^{[1
]}

Trallero, G. ^{[1
]}

Cabrerizo, M. ^{[1
]}

Casas, I. ^{[1
]}

Pozo, F. ^{[1
]}

Fedele, G. ^{[1
]}

Vicente, D. ^{[3
]}

Pena, M. J. ^{[4
]}

Moreno, A. ^{[5
]}

Niubo, J. ^{[6
]}

Rabella, N. ^{[7
]}

Rubio, G. ^{[8
]}

Perez-Ruiz, M. ^{[9
]}

Rodriguez-Iglesias, M. ^{[10
]}

Gimeno, C. ^{[11
]}

Eiros, J. M. ^{[12
]}

Melon, S. ^{[13
]}

Blasco, M. ^{[14
]}

Lopez-Miragaya, I. ^{[15
]}

Varela, E. ^{[16
]}

Martinez-Sapina, A. ^{[17
]}

Rodriguez, G. ^{[18
]}

Marcos, M. A. ^{[19
]}

Gegundez, M. I. ^{[20
]}

Cilla, G. ^{[3
]}

Gabilondo, I. ^{[8
]}

Navarro, J. M. ^{[9
]}

Torres, J. ^{[15
]}

Aznar, C. ^{[1
,2
]}

Castellanos, A. ^{[1
,2
]}

Guisasola, M. E. ^{[1
,2
]}

Negredo, A. I. ^{[1
]}

Tenorio, A. ^{[1
]}

Vazquez-Moron, S. ^{[1
,2
]}

机构：

[1] Natl Ctr Microbiol, Majadahonda, Spain

[2] CIBERESP, Majadahonda, Spain

[3] Hosp Donostia, San Sebastian, Spain

[4] Hosp Univ Gran Canaria Dr Negrin, Las Palmas Gran Canaria, Spain

[5] Hosp Virgen Arrixaca, Murcia, Spain

[6] Bellvitge Hosp, Lhospitalet De Llobregat, Spain

[7] Hosp Santa Creu & Sant Pau, Barcelona, Spain

[8] Hosp Cruces, Baracaldo, Spain

[9] Hosp Virgen de las Nieves, Granada, Spain

[10] Hosp Puerto Real, Puerto Real, Spain

[11] Gen Hosp, Valencia, Spain

[12] Hosp Clin Univ, Valladolid, Spain

[13] Hosp Univ Cent Asturias, Oviedo, Spain

[14] Hosp San Millan & San Pedro, Logrono, Spain

[15] Hosp Meixoeiro, Vigo, Spain

[16] Hosp Clin Univ, Santiago De Compostela, Spain

[17] Hosp Miguel Servet, Zaragoza, Spain

[18] Hosp San Pedro Alcantara, Caceres, Spain

[19] Hosp Clin Barcelona, Barcelona, Spain

[20] Univ Alcala de Henares, Alcala De Henares, Spain

来源：

JOURNAL OF MEDICAL VIROLOGY | 2013年 / 85卷 / 03期

关键词：

aseptic meningitis; encephalitis; meningoencephalitis; enterovirus; herpes simplex virus; varicella-zoster virus; polymerase chain reaction; serology; viral infections; central nervous system; incidence; WEST-NILE-VIRUS; RT-NESTED-PCR; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MUMPS-VIRUS; CEREBROSPINAL-FLUID; CLINICAL-SAMPLES; HERPES-SIMPLEX; MOLECULAR CHARACTERIZATION; ACUTE MENINGOENCEPHALITIS; ASEPTIC-MENINGITIS;

D O I：

10.1002/jmv.23470

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The aim of the study was to determine the incidence of viruses causing aseptic meningitis, meningoencephalitis, and encephalitis in Spain. This was a prospective study, in collaboration with 17 Spanish hospitals, including 581 cases (CSF from all and sera from 280): meningitis (340), meningoencephalitis (91), encephalitis (76), febrile syndrome (7), other neurological disorders (32), and 35 cases without clinical information. CSF were assayed by PCR for enterovirus (EV), herpesvirus (herpes simplex [HSV], varicella-zoster [VZV], cytomegalovirus [CMV], EpsteinBarr [EBV], and human herpes virus-6 [HHV-6]), mumps (MV), Toscana virus (TOSV), adenovirus (HAdV), lymphocytic choriomeningitis virus (LCMV), West Nile virus (WNV), and rabies. Serology was undertaken when methodology was available. Amongst meningitis cases, 57.1% were characterized; EV was the most frequent (76.8%), followed by VZV (10.3%) and HSV (3.1%; HSV-1: 1.6%; HSV-2: 1.0%, HSV non-typed: 0.5%). Cases due to CMV, EBV, HHV-6, MV, TOSV, HAdV, and LCMV were also detected. For meningoencephalitis, 40.7% of cases were diagnosed, HSV-1 (43.2%) and VZV (27.0%) being the most frequent agents, while cases associated with HSV-2, EV, CMV, MV, and LCMV were also detected. For encephalitis, 27.6% of cases were caused by HSV-1 (71.4%), VZV (19.1%), or EV (9.5%). Other positive neurological syndromes included cerebellitis (EV and HAdV), seizures (HSV), demyelinating disease (HSV-1 and HHV-6), myelopathy (VZV), and polyradiculoneuritis (HSV). No rabies or WNV cases were identified. EVs are the most frequent cause of meningitis, as is HSV for meningoencephalitis and encephalitis. A significant number of cases (42.9% meningitis, 59.3% meningoencephalitis, 72.4% encephalitis) still have no etiological diagnosis. J. Med. Virol. 85:554562, 2013. (c) 2012 Wiley Periodicals, Inc.

引用

页码：554 / 562

页数：9

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