Quinic acid derivatives from Pimpinella brachycarpa exert anti-neuroinflammatory activity in lipopolysaccharide-induced microglia

被引：54

作者：

Lee, Seung Young ^{[1
]}

Moon, Eunjung ^{[2
]}

Kim, Sun Yeou ^{[2
,3
]}

Lee, Kang Ro ^{[1
]}

机构：

[1] Sungkyunkwan Univ, Sch Pharm, Nat Prod Lab, Suwon 440746, Gyeonggi Do, South Korea

[2] Gachon Univ, Gachon Inst Pharmaceut Sci, Inchon 406799, South Korea

[3] Gachon Univ, Coll Pharm, Inchon 406799, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2013年 / 23卷 / 07期

基金：

新加坡国家研究基金会;

关键词：

Pimpinella brachycarpa; Umbelliferae; Quinic acid derivative; Anti-inflammatory effect; PHENOLIC-COMPOUNDS; CHLOROGENIC ACID; IDENTIFICATION; CONSTITUENTS;

D O I：

10.1016/j.bmcl.2013.01.115

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Five new quinic acid derivatives (1-5), together with 10 known quinic acid derivatives (6-15), were isolated from the MeOH extract of Pimpinella brachycarpa (Umbelliferae). Their structures were established on the basis of spectroscopic analyses including extensive 2D NMR studies (COSY, HMQC and HMBC). Isolated compounds 1-15 were evaluated for their inhibitory activities on nitric oxide (NO) production in an activated murine microglial cell line. Compounds 2, 3, 8 and 11 significantly inhibited NO production without high cell toxicity in lipopolysaccharide (LPS)-activated BV-2 cells, a microglia cell line (IC50 = 4.66, 12.52, 9.04 and 12.11 mu M, respectively). (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：2140 / 2144

页数：5

共 2 条

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