The contribution of hybrid SPECT/CT imaging in the management of differentiated thyroid carcinoma

Introduction. Single photon emission computed tomography combined with a low dose computed tomography (SPECT/CT), is a hybrid imaging integrating functional and anatomical data. The purpose of our study was to evaluate the contribution of the SPECT/CT over traditional planar imaging of patients with differentiated thyroid carcinoma (DTC). Methods. Post-therapy iodine 131 (I-131) whole-body scan followed by cervico-thoracic SPECT/CT, were performed in 100 patients with DTC. Results. Among these 100 patients followed for a predominantly papillary DTC, planar imaging and SPECT/CT, were perfectly concordant in 70% of patients and discordant in the remaining 30%. The use of fusion imaging SPECT/CT compared to conventional planar imaging allowed us to correct our therapeutic approach in 27% (27/100 patients), according to the protocols of therapeutic management of our institute. Conclusion. SPECT/CT is a hybrid imaging modality which provides better identification and more correct anatomic localization of the foci of radioiodine uptake with impact on therapeutic management. (C) 2012 Elsevier Masson SAS. All rights reserved.