In vitro evaluation of a poly(lactide-co-glycolide)-collagen composite scaffold for bone regeneration

被引：74

作者：

Lee, SJ ^{[1
]}

Lim, GJ ^{[1
]}

Lee, JW ^{[1
]}

Atala, A ^{[1
]}

Yoo, JJ ^{[1
]}

机构：

[1] Wake Forest Univ, Sch Med, Wake Forest Inst Regenerat Med, Winston Salem, NC 27157 USA

来源：

BIOMATERIALS | 2006年 / 27卷 / 18期

关键词：

bladder submucosa matrix; poly(D; L-lactide-co-glycolide); scaffold; bone tissue regeneration;

D O I：

10.1016/j.biomaterials.2006.01.059

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Numerous materials have been proposed for bone tissue regeneration. However, none has been shown to be entirely satisfactory. In this Study we fabricated a hybrid composite scaffold composed Of poly(D,L-lactide-co-glycolide) (PLGA) and a naturally derived collagen matrix derived from porcine bladder submucosa matrix (BSM), and evaluated the biological activities and physical properties of the scaffold for use in bone tissue regeneration. The BSM-PLGA composite scaffolds are able to promote cellular interactions and possess uniformly interconnected pores with adequate structural integrity. The composite scaffolds were tested with both human embryonic stern (hES) cells and bovine osteoblasts (bOB). Cells seeded on the composite scaffolds readily attached, infiltrated and proliferated, as confirmed by cell viability and mitochondrial metabolic activity. Use of the composite scaffolding system with cells may enhance the formation of bone tissue for therapeutic regeneration. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：3466 / 3472

页数：7

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