Impacts of Psychological Stress on Osteoporosis: Clinical Implications and Treatment Interactions

被引:66
作者
Kelly, Ryan R. [1 ,2 ]
McDonald, Lindsay T. [1 ,2 ]
Jensen, Nathaniel R. [1 ,2 ]
Sidles, Sara J. [1 ,2 ]
LaRue, Amanda C. [1 ,2 ]
机构
[1] Ralph H Johnson VA Med Ctr, Res Serv, Charleston, SC 29401 USA
[2] Med Univ South Carolina, Dept Pathol & Lab Med, Charleston, SC 29425 USA
来源
FRONTIERS IN PSYCHIATRY | 2019年 / 10卷
关键词
osteoporosis; bone; psychological stress; mental health; depression; PTSD; pharmacology; alternatives; BONE-MINERAL DENSITY; SEROTONIN-REUPTAKE INHIBITORS; VITAMIN-D SUPPLEMENTATION; QUALITY-OF-LIFE; VERTEBRAL FRACTURE RISK; POSTMENOPAUSAL WOMEN; STRONTIUM RANELATE; FISH-OIL; HIPPOCAMPAL NEUROGENESIS; INTEROCEPTIVE EXPOSURE;
D O I
10.3389/fpsyt.2019.00200
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
The significant biochemical and physiological effects of psychological stress are beginning to be recognized as exacerbating common diseases, including osteoporosis. This review discusses the current evidence for psychological stress-associated mental health disorders as risk factors for osteoporosis, the mechanisms that may link these conditions, and potential implications for treatment. Traditional, alternative, and adjunctive therapies are discussed. This review is not intended to provide therapeutic recommendations, but, rather, the goal of this review is to delineate potential interactions of psychological stress and osteoporosis and to highlight potential multi-system implications of pharmacological interventions. Review of the current literature identifies several potentially overlapping mechanistic pathways that may be of interest (e.g., glucocorticoid signaling, insulin-like growth factor signaling, serotonin signaling) for further basic and clinical research. Current literature also supports the potential for cross-effects of therapeutics for osteoporosis and mental health disorders. While studies examining a direct link between osteoporosis and chronic psychological stress are limited, the studies reviewed herein suggest that a multi-factorial, personalized approach should be considered for improved patient outcomes in populations experiencing psychological stress, particularly those at high-risk for development of osteoporosis.
引用
收藏
页数:21
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