HepG2 hepatocellular carcinoma cells are a non-permissive system for B19 virus infection

被引:10
作者
Bonvicini, Francesca [1 ]
Filippone, Claudia [1 ]
Manaresi, Elisabetta [1 ]
Zerbini, Marialuisa [1 ]
Musiani, Monica [1 ]
Gallinella, Giorgio [1 ]
机构
[1] Univ Bologna, Dept Microbiol, Bologna, Italy
关键词
D O I
10.1099/vir.0.2008/004341-0
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Parvovirus 1319 has been associated with liver dysfunction and has been considered a potential aetiological agent of fulminant hepatitis and hepatitis-associated aplastic; anaemia. The possible effects of B19 virus infection on the liver have been investigated using HepG2 hepatocellular carcinoma cells as a model system, but the reported results are inconsistent. To investigate this relationship further, this study followed the course of B19 virus infection of HepG2 cells in terms of viral DNA, RNA and protein production by quantitative PCR, RT-PCR and immunofluorescence assays. The data showed that B 19 virus is able to bind and possibly enter HepG2 cells, but that viral genome replication or transcription is not supported and that viral proteins are not produced. As far as HepG2 cells can be considered a representative model system, any possible pathogenic role of B19 virus on the liver cannot be ascribed to infection or to a direct cytopathic effect on hepatocytes.
引用
收藏
页码:3034 / 3038
页数:5
相关论文
共 50 条
  • [21] Synergistic antiproliferative effects of curcumin and celecoxib in hepatocellular carcinoma HepG2 cells
    Abdallah, Fatma M.
    Helmy, Maged W.
    Katary, Mohamed A.
    Ghoneim, Asser I.
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2018, 391 (12) : 1399 - 1410
  • [22] Effect of taurine on the proliferation and apoptosis of human hepatocellular carcinoma HepG2 cells
    Tu, Shuo
    Zhang, Xiali
    Luo, Daya
    Liu, Zhuoqi
    Yang, Xiaohong
    Wan, Huifang
    Yu, Lehan
    Li, Hua
    Wan, Fusheng
    EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2015, 10 (01) : 193 - 200
  • [23] ANALYSIS OF GLUCOCORTICOID RECEPTORS IN HUMAN HEPATOCELLULAR-CARCINOMA AND HEPG2 CELLS
    LUI, WY
    PENG, FK
    CHANG, YF
    CHANG, TJ
    TSAI, TF
    HSU, ML
    SU, TS
    TSAY, SH
    WU, CW
    LIU, TY
    CHI, CW
    HEPATOLOGY, 1993, 18 (05) : 1167 - 1174
  • [24] Antiproliferative and Apoptotic Effects of Cardamonin against Hepatocellular Carcinoma HepG2 Cells
    Badroon, Nassrin A.
    Abdul Majid, Nazia
    Alshawsh, Mohammed A.
    NUTRIENTS, 2020, 12 (06) : 1 - 20
  • [25] Regulation of alternative SRC promoter usage in HepG2 hepatocellular carcinoma cells
    Dehm, SM
    Bonham, K
    GENE, 2004, 337 : 141 - 150
  • [26] Proteomie analysis of hepatocellular carcinoma HepG2 cells treated with platycodin D
    Liu, J. J.
    Lu, D. Z.
    Chen, Y. F.
    Dong, Y. T.
    Yang, Z.
    CHINESE JOURNAL OF NATURAL MEDICINES, 2015, 13 (09)
  • [27] Cytotoxicity of allyl isothiocyanate and its metabolites in hepatocellular carcinoma HepG2 cells
    Hashimoto, Takashi
    Nakamura, Shino
    Suzuki, Takeshi
    Hasegawa, Yuka
    Kanazawa, Kazuki
    MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2025, 830
  • [28] Proteomic analysis of hepatocellular carcinoma HepG2 cells treated with platycodin D
    LU Jin-Jian
    LU De-Zhao
    CHEN Yu-Fei
    DONG Ya-Ting
    ZHANG Jun-Ren
    LI Ting
    TANG Zheng-Hai
    YANG Zhen
    ChineseJournalofNaturalMedicines, 2015, 13 (09) : 673 - 679
  • [29] Hypolipidemic effects of quercetin and kaempferol in human hepatocellular carcinoma (HepG2) cells
    Yusof, H. M.
    Sarah, Ng M. L.
    Lam, T. W.
    Kassim, M. N., I
    INTERNATIONAL FOOD RESEARCH JOURNAL, 2018, 25 (01): : 241 - 245
  • [30] Biochemical effects of copper nanomaterials in human hepatocellular carcinoma (HepG2) cells
    Kirk T. Kitchin
    Judy A. Richards
    Brian L. Robinette
    Kathleen A. Wallace
    Najwa H. Coates
    Benjamin T. Castellon
    Eric A. Grulke
    Cell Biology and Toxicology, 2023, 39 (5) : 2311 - 2329