THE D-LIGHTFUL VITAMIN D FOR HEALTH

被引:18
作者
Holick, Michael F. [1 ]
机构
[1] Boston Univ, Sect Endocrinol Nutr & Diabet, Vitamin Skin & Bone Res Lab D, Dept Med,Sch Med,Med Ctr, Boston, MA 02118 USA
关键词
vitamin D; cancer; sunlight; 25-hydroxyvitamin D; infectious disease; osteoporosis; rickets; 25-HYDROXYVITAMIN D CONCENTRATIONS; D DEFICIENCY; RANDOMIZED-TRIAL; HIGH PREVALENCE; ULTRAVIOLET-B; SUN EXPOSURE; CANCER-RISK; CALCIUM; SUPPLEMENTATION; DISEASE;
D O I
10.2478/v10011-012-0025-y
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Vitamin D is the sunshine vitamin that is not only important for children's and adults' skeletal health but is also important for their overall health and wellbeing. Vitamin D deficiency has been defined as a 25-hydroxyvitamin D < 20 ng/mL and vitamin D insufficiency as a 25-hydroxyvitamin D of 21-29 ng/mL. The major source of vitamin D is sensible sun exposure since very few foods naturally contain vitamin D. Vitamin D deficiency is associated with increased risk for many acute and chronic diseases including infectious diseases, autoimmune diseases, cardiovascular disease, type 2 diabetes, neurocognitive dysfunction and muscle weakness. To achieve a blood level of 25-hydroxyvitamin D > 30 ng/mL children require 600-1 000 IUs and adults 1 500-2 000 IUs of vitamin D daily.
引用
收藏
页码:1 / 10
页数:10
相关论文
共 73 条
[1]  
[Anonymous], 1956, BRIT MED J, V2, P149
[2]  
[Anonymous], DIET REF INT CALC VI
[3]   Fortification of orange juice with vitamin D2 or vitamin D3 is as effective as an oral supplement in maintaining vitamin D status in adults [J].
Biancuzzo, Rachael M. ;
Young, Azzie ;
Bibuld, Douglass ;
Cai, Mona H. ;
Winter, Michael R. ;
Klein, Ellen K. ;
Ameri, Allen ;
Reitz, Richard ;
Salameh, Wael ;
Chen, Tai C. ;
Holick, Michael F. .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 2010, 91 (06) :1621-1626
[4]   Calcitriol-induced apoptosis in LNCaP cells is blocked by overexpression of bcl-2 [J].
Blutt, SE ;
McDonnell, TJ ;
Polek, TC ;
Weigel, NL .
ENDOCRINOLOGY, 2000, 141 (01) :10-17
[5]   A phase I/II dose-escalation trial of vitamin D3 and calcium in multiple sclerosis [J].
Burton, J. M. ;
Kimball, S. ;
Vieth, R. ;
Bar-Or, A. ;
Dosch, H. -M. ;
Cheung, R. ;
Gagne, D. ;
D'Souza, C. ;
Ursell, M. ;
O'Connor, P. .
NEUROLOGY, 2010, 74 (23) :1852-1859
[6]   Healthy elderly French women living at home have secondary hyperparathyroidism and high bone turnover in winter [J].
Chapuy, MC ;
Schott, AM ;
Garnero, P ;
Hans, D ;
Delmas, PD ;
Meunier, PJ ;
Breart, G ;
Dargent, P ;
Haussher, E ;
Cormier, C ;
Sebert, JL ;
Favier, F ;
Marcelli, C ;
Grandjean, H ;
Ribot, C .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1996, 81 (03) :1129-1133
[7]   Vitamin D signalling pathways in cancer: potential for anticancer therapeutics [J].
Deeb, Kristin K. ;
Trump, Donald L. ;
Johnson, Candace S. .
NATURE REVIEWS CANCER, 2007, 7 (09) :684-700
[8]   Low serum 25-hydroxyvitamin D level predicts progression to type 2 diabetes in individuals with prediabetes but not with normal glucose tolerance [J].
Deleskog, A. ;
Hilding, A. ;
Brismar, K. ;
Hamsten, A. ;
Efendic, S. ;
Ostenson, C. -G. .
DIABETOLOGIA, 2012, 55 (06) :1668-1678
[9]  
El-Hajj Fuleihan G, 2010, NUTR HEALTH SER, P469, DOI 10.1007/978-1-60327-303-9_24
[10]  
Feskanich D, 2004, CANCER EPIDEM BIOMAR, V13, P1502