Role of membranes in the activities of antimicrobial cationic peptides

被引：386

作者：

Hancock, REW ^{[1
]}

Rozek, A ^{[1
]}

机构：

[1] Univ British Columbia, Dept Microbiol & Immunol, Vancouver, BC V6T 1Z3, Canada

来源：

FEMS MICROBIOLOGY LETTERS | 2002年 / 206卷 / 02期

关键词：

antimicrobial peptide; cationic peptide; membrane; model membrane; mode of action;

D O I：

10.1016/S0378-1097(01)00480-3

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Cationic amphiphilic peptides that are found throughout nature have very broad-spectrum activities against microbes. The initial sites of interaction are with microbial membranes. Although dogma suggests that their lethal action involves disruption of the cytoplasmic membranes. a number of cationic peptides can traverse intact membranes to interact with internal targets. (C) 2002 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：143 / 149

页数：7

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